Overall survival after stereotactic radiotherapy or surgical metastasectomy in oligometastatic renal cell carcinoma patients treated at two Swedish centres 2005-2014

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Maria StenmanMagnus Lindskog

Abstract

Investigate effects of stereotactic radiotherapy (SRT) or surgical metastasectomy (SM) on overall survival (OS) in metastatic renal cell carcinoma (mRCC) in the era of targeted agents (TA). mRCC patients (n = 117) treated with SRT (n = 57), SM (n = 30) or both modalities sequentially (n = 30) at two oncological centres in Sweden in 2005-2014 were retrospectively included. Median follow-up (mFU) was 63 months. A majority had clear cell histology, 1-3 metastases, and ECOG performance status of 0 or 1. Two thirds had intermediate or poor risk and 44% synchronous metastases. 65% received TA. SRT patients were more likely to have adverse risk profiles. Median OS was 51 months without significant differences between SRT and SM. ECOG 1 vs 0 (HR 2.9; CI 1.6-5.2; p < 0.001), intracranial targets (HR 1.8; CI 1.1-3.2; p = 0.03) and watchful waiting >18 months prior to treatment (HR 0.3; CI 0.2-0.6; p = 0.001) were independently associated with OS. 15% of curatively treated patients (n = 60) were relapse-free with mFU of 87 months. OS after SRT was comparable to SM and longer than expected considering patients with adverse risk profiles were common. Fit patients with non-brain metastases treated after an initial period of watchful waiting ...Continue Reading

Citations

Nov 21, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Janice P Dutcher
Jun 2, 2020·Expert Review of Anticancer Therapy·Maddalena DoniniMatteo Santoni
May 29, 2020·Current Opinion in Urology·Sara OmidMesut Remzi
Sep 19, 2020·The Cancer Journal·Michael DohopolskiAurelie Garant
Oct 29, 2020·BJU International·Stephanie G C KroezeMatthias Guckenberger
Feb 6, 2021·Critical Reviews in Oncology/hematology·Gianluca IngrossoBeatrice Detti
Dec 12, 2020·BMJ Case Reports·Shawn David EllisGeorges Sinclair
Mar 21, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Carsten NiederAnca L Grosu
Mar 10, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G MarvasoB A Jereczek-Fossa
Jun 7, 2021·Seminars in Radiation Oncology·Sean AllRaquibul Hannan

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