Overall survival for neuroblastoma in South Africa between 2000 and 2014

Pediatric Blood & Cancer
Jaques Van HeerdenMariana Kruger

Abstract

Outcome data for neuroblastoma in sub-Saharan Africa are minimal, whereas poor outcome is reported in low- and middle-income countries. A multi-institutional retrospective study across South Africa was undertaken to determine outcome. Patients treated between January 2000 and December 2014 in nine South African pediatric oncology units were included. Kaplan-Meier curves and Cox regression models were employed to determine two-year survival rates and to identify prognostic factors. Data from 390 patients were analyzed. The median age was 39.9 months (range, 0-201 months). The majority presented with stage 4 disease (70%). The main chemotherapy regimens were OPEC/OJEC (44.8%), St Jude NB84 protocol (28.96%), and Rapid COJEC (22.17%). Only 44.4% had surgery across all risk groups, whereas only 16.5% of high-risk patients received radiotherapy. The two-year overall survival (OS) for the whole cohort was 37.6%: 94.1%, 81.6%, and 66.7%, respectively, for the very-low-risk, low-risk, and intermediate-risk groups and 27.6% for the high-risk group (P < 0.001, 95% CI). The median survival time for the whole group was 13 months (mean, 41.9 months; range, 0.1-209 months). MYCN-nonamplified patients had a superior two-year OS of 51.3% in co...Continue Reading

References

Sep 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C BowmanW M Crist
Sep 1, 1989·Radiographics : a Review Publication of the Radiological Society of North America, Inc·R DavidJ E Madewell
Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M BrodeurF Hedborg
Dec 13, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CozeJ L Bernard
Feb 8, 2006·Journal of Pediatric Hematology/oncology·Ivy Zortéa S PariseBonald C Figueiredo
May 31, 2007·Annals of the Royal College of Surgeons of England·Edward Kiely
Mar 1, 2008·The Lancet Oncology·Andrew D J PearsonUNKNOWN Children's Cancer and Leukaemia Group (CCLG formerly United Kingdom Children's Cancer Study Group)
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L CohnUNKNOWN INRG Task Force
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Riccardo HauptBruno De Bernardi
Apr 21, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Trijn IsraelsElizabeth M Molyneux
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tara O HendersonSusan L Cohn
Feb 15, 2012·Advances in Nutrition·Jacqueline BauerMichael C Frühwald
Dec 4, 2012·Lancet·Bongani M MayosiUNKNOWN Lancet South Africa team
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris DecarolisMatthias Schmidt
Feb 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gregory A YanikKatherine K Matthay
Mar 12, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·S R Benatar
Sep 30, 2014·The New England Journal of Medicine·Bongani M Mayosi, Solomon R Benatar
Mar 15, 2015·Clinical Epigenetics·Yania YáñezVictoria Castel
Mar 27, 2015·Pediatric Blood & Cancer·Nehal S ParikhUNKNOWN International Society of Pediatric Oncology
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navin R PintoSusan L Cohn
Dec 2, 2015·Oncology Letters·Youssef Al-TonbaryAhmad Darwish
Dec 4, 2015·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·D C StefanE Steliarova-Foucher
Nov 11, 2016·Nature Reviews. Disease Primers·Katherine K MatthayWilliam A Weiss
Nov 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel von AllmenMichael P La Quaglia
Feb 2, 2017·Expert Review of Anticancer Therapy·Sarah B WhittlePeter E Zage
May 5, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R ParkDominique Valteau-Couanet
Aug 30, 2018·Children·Valeria Smith, Jennifer Foster

❮ Previous
Next ❯

Citations

Feb 23, 2020·Pediatric Hematology and Oncology·Jaques Van HeerdenMariana Kruger
Feb 4, 2021·Pediatric Blood & Cancer·Jaques van HeerdenWim Pinxten
Mar 31, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·J Van HeerdenA Brink
Apr 22, 2021·Cancer Causes & Control : CCC·Jaques van HeerdenUNKNOWN SACCSG Neuroblastoma Workgroup
Aug 30, 2021·Pediatric Blood & Cancer·Jennifer Ann GeelJulia Challinor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Shakeel ModakNai-Kong V Cheung
© 2021 Meta ULC. All rights reserved