Overall survival of stage IV non-small cell lung cancer patients treated with Viscum album L. in addition to chemotherapy, a real-world observational multicenter analysis

PloS One
Friedemann SchadHarald Matthes

Abstract

Stage IV non-small cell lung cancer (NSCLC) is associated with a five-year survival rate of around 1%. Treatment with Viscum album L. (VA) extracts has been shown to reduce chemotherapy (CTx)-related adverse events, decrease CTx dose reductions and improve quality of life in a number of cancers. Recent data suggest a beneficial effect of add-on treatment with Viscum album L. (VA, European mistletoe) on survival in cancer patients. The objective of this study was to evaluate the effect of VA in addition to chemotherapy on survival in stage IV NSCLC patients. The observational study was conducted using data from the Network Oncology clinical registry which is an accredited conjoint clinical registry of German oncological hospitals, practitioners and out-patient centers.Patients were included if they had stage IV NSCLC at diagnosis, lived at least for four weeks post-diagnosis and received chemotherapeutic treatment. Patients with EGFR mutations as well as patients receiving tyrosine kinase inhibitors or immune checkpoint inhibitors were not included. Overall survival and impact on hazard in patients with chemotherapy (CTx) to patients receiving CTx plus VA were compared. To identify factors associated with survival and to address...Continue Reading

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Citations

Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Anja ThronickeFriedemann Schad
Feb 19, 2019·World Journal of Gastroenterology : WJG·Dong Kyun KimYang Hyun Baek
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Anja ThronickeFriedemann Schad
Jan 19, 2021·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Ricardo R Bartelme
Mar 25, 2021·Scientific Reports·Marta ZerunianAndrea Laghi
May 28, 2021·Journal of Ethnopharmacology·Chuan SongBin Yang

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Software Mentioned

R
package ‘ survival
prodlim
survminer
Studio

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