Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire

The Journal of Infectious Diseases
Katherine A RichardsAndrea J Sant

Abstract

There is limited information on the antigen specificity and functional potential of the influenza virus-specific CD4+ T-cell repertoire in humans. Here, enzyme-linked immunospot assays were used to examine circulating CD4+ T-cell specificities for influenza virus directly ex vivo in healthy adults. Our studies revealed CD4+ T-cell reactivity to multiple influenza virus proteins, including hemagglutinins, neuraminidases, M1 proteins, and nucleoproteins. Unexpectedly, the immunodominance hierarchies and functional potential of cells reactive toward influenza A virus were distinct from those toward influenza B virus. We also identified influenza virus-specific cells producing granzyme B. Our findings revealed individual and virus-specific patterns that may differentially poise humans to respond to infection or vaccination.

References

Oct 10, 2008·Journal of Virology·Erika AssarssonAlessandro Sette
Jan 19, 2013·American Journal of Public Health·W Paul GlezenJohn Oxford
Sep 17, 2014·Nature Communications·Edward C HutchinsonErvin Fodor
Nov 8, 2014·The Journal of Infectious Diseases·Jennifer L NayakAndrea J Sant
Apr 7, 2015·American Journal of Respiratory and Critical Care Medicine·Andrew C HaywardAndrew J McMichael
Jan 20, 2016·Nature Reviews. Immunology·Brian J LaidlawSusan M Kaech
Mar 26, 2016·Frontiers in Immunology·Deborah M BrownAspen M Workman
Aug 31, 2016·Nature Communications·Hannes UchtenhagenEddie A James
Apr 6, 2018·Current Opinion in Immunology·Andrea J SantJennifer Nayak

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Citations

Aug 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony T DiPiazzaAndrea J Sant
Aug 9, 2020·Expert Review of Respiratory Medicine·John StambasRalph A Tripp
Aug 20, 2020·Future Microbiology·Luca HensenMarios Koutsakos
Nov 12, 2019·International Reviews of Immunology·Asim BiswasShanta Dutta
May 28, 2019·Frontiers in Immunology·Sean A Nelson, Andrea J Sant
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·David J TophamAndrea Sant

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