Overcoming cytoplasmic incompatibility in Drosophila

Proceedings. Biological Sciences
Timothy L KarrM E Feder

Abstract

The endocellular microbe Wolbachia pipientis infects a wide variety of invertebrate species, in which its presence is closely linked to a form of reproductive failure termed cytoplasmic incompatibility (CI). CI renders infected males unable to father offspring when mated to uninfected females. Because CI can dramatically affect fitness in natural populations, mechanisms that abate CI can have equally large impacts on fitness. We have discovered that repeated copulation by Wolbachia-infected male Drosophila simulans significantly diminishes CI. Repeated copulation does not prevent Wolbachia from populating developing spermatids, but may reduce the time during spermatogenesis when Wolbachia can express CI. This restoration of fertility in premated infected males could have important implications for Wolbachia transmission and persistence in nature and for its exploitation as an agent of biological pest control.

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Citations

Jul 17, 2013·Insect Biochemistry and Molecular Biology·John F Beckmann, Ann M Fallon
Jun 12, 2002·Biological Reviews of the Cambridge Philosophical Society·T Pizzari, T R Birkhead
Jan 23, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nina Wedell
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Jan 5, 2013·Insect Biochemistry and Molecular Biology·John F BeckmannAnn M Fallon
Dec 11, 2007·Evolution; International Journal of Organic Evolution·Fleur E Champion de CrespignyNina Wedell
Sep 8, 2015·Current Biology : CB·Stéphanie M Pontier, François Schweisguth
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harriet L Harris, Henk R Braig
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Oct 3, 2018·Ecology and Evolution·Martin D Garlovsky, Rhonda R Snook
Jun 26, 2020·Frontiers in Microbiology·Mariana MateosGeorge Tsiamis
Oct 20, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rudi L VerspoorNina Wedell
Jun 22, 2021·Arthropod-plant Interactions·Gabriela E PonceEdward F Connor

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