Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology

International Journal of Nanomedicine
Pei-Yao XuAi-Zheng Chen

Abstract

In recent times, the co-delivery therapeutics have garnered enormous interest from researchers in the treatment of cancers with multidrug resistance (MDR) due to their efficient delivery of multiple agents, which result in synergistic effects and capable of overcoming all the obstacles of MDR in cancer. However, an efficient delivery platform is required for the conveyance of diverse agents that can successfully devastate MDR in cancer. Initially, short-interfering RNA-loaded chitosan (siRNA-CS) nanoparticles were synthesized using the ionic gelation method. Further, the siRNA-CS nanoparticles and doxorubicin hydrochloride (DOX) were co-loaded in poly-L-lactide porous microparticles (PLLA PMs) (nano-embedded porous microparticles, [NEPMs]) by the supercritical anti-solvent (SAS) process. The NEPM formulation exhibited an excellent aerodynamic performance and sustained release of DOX, which displayed higher anticancer efficacy in drug-resistant cells (human small cell lung cancer, H69AR cell line) than those treated with either free DOX and DOX-PLLA PMs due to the siRNA from CS nanoparticles silenced the MDR gene to DOX therapy. This eco-friendly process provides a convenient way to fabricate such innovative NEPMs co-loaded with...Continue Reading

Citations

Nov 7, 2019·Drug Development Research·Kamal DuaDinesh Kumar Chellappan
Oct 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo TangGuihua Fang
Oct 31, 2020·International Journal of Pharmaceutics·A Sofia SilvaPaula T Hammond
Feb 5, 2021·ACS Biomaterials Science & Engineering·Pei-Yao XuAi-Zheng Chen
Nov 12, 2020·Advanced Science·Ying WangAizheng Chen
Nov 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ling DingDavid Oupický
Aug 10, 2021·Molecular Aspects of Medicine·Alysia CoxEun Ji Chung

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Methods Mentioned

BETA
scanning electron microscopy
dynamic light scattering
infrared spectroscopy
fluorescence imaging

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