DOI: 10.1101/458372Nov 8, 2018Paper

Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

BioRxiv : the Preprint Server for Biology
Sara NizzeroJavier Torres-Roca


Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Revue des maladies respiratoires
F Chermiti Ben AbdallahA Ben Kheder
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Alexander V Louie, Suresh Senan
Annals of Oncology : Official Journal of the European Society for Medical Oncology
D Propper, D C Talbot
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Rohit LalHartmut Kristeleit
© 2021 Meta ULC. All rights reserved