Nov 8, 2018

Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem

BioRxiv : the Preprint Server for Biology
Sara NizzeroJavier Torres-Roca

Abstract

Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.

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Mentioned in this Paper

Immune Response
Tumor Immunity
Immune Response to Tumor Cell
Cessation of Life
Non-Small Cell Lung Cancer Pathway
Neoplasms
Radiation Resistance
Non-Small Cell Lung Carcinoma
Carcinoma of Lung
Therapeutic Radiology Procedure

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