Overcoming obstacles to repurposing for neurodegenerative disease

Annals of Clinical and Translational Neurology
Diana ShinemanHoward M Fillit

Abstract

Repurposing Food and Drug Administration (FDA)-approved drugs for a new indication may offer an accelerated pathway for new treatments to patients but is also fraught with significant commercial, regulatory, and reimbursement challenges. The Alzheimer's Drug Discovery Foundation (ADDF) and the Michael J. Fox Foundation for Parkinson's Research (MJFF) convened an advisory panel in October 2013 to understand stakeholder perspectives related to repurposing FDA-approved drugs for neurodegenerative diseases. Here, we present opportunities on how philanthropy, industry, and government can begin to address these challenges, promote policy changes, and develop targeted funding strategies to accelerate the potential of FDA-approved repurposed drugs.

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Citations

Jan 1, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tae-Wan Kim
Apr 4, 2017·British Journal of Pharmacology·Y ChaD Laifenfeld
Apr 19, 2017·Assay and Drug Development Technologies·Katarzyna Styczyńska-SoczkaLysimachos Zografos
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Related Concepts

Foundations
Nerve Degeneration
Research
United States Food and Drug Administration
Pharmacologic Substance
Administration of Medication
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