Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Evidence-based Complementary and Alternative Medicine : ECAM
Gayoung LeeNamhun Lee

Abstract

Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P-glycoprotein (P-gp) in cancer tissues. Despite research efforts to overcome P-gp-mediated drug efflux, the high toxicity of P-gp inhibitors has been a major obstacle for the clinical use of these agents. The aim of this study was to review the literature for potential P-gp reversal agents among traditional herbal medicines, which offer the advantages of safety and potential synergetic effects in CRC chemotherapy. We searched ten databases including 3 English databases, 1 Chinese medical database, and 6 Korean medical databases up to July 2018 and included in vivo and in vitro studies evaluating the effects of herbal medicines as P-gp reversal agents in CRC. A total of 28 potentially related studies were identified and 16 articles were included. Involving 3 studies about Salvia miltiorrhiza and 2 studies about Curcuma longa, finally we found 14 kinds of traditional herbal medicines-Salvia miltiorrhiza, Curcuma longa, Sinomenium acutum, Stephania tetrandra, Bufo gargarizans, Coptis japonica, Piper nigrum and Piper longum, He...Continue Reading

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Citations

Apr 21, 2020·Phytotherapy Research : PTR·Saeedeh Keyvani-GhamsariAsma Gul
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Rabia Shabir AhmadMohammad Hashem Hashempur
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Oct 30, 2020·Drug Design, Development and Therapy·Nasrul WathoniMuchtaridi Muchtaridi
Apr 27, 2021·Pediatric Hematology and Oncology·Gabriela Antonio-AndresSara Huerta-Yepez
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinru HanShuwen Yu

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