Overcoming photodynamic resistance and tumor targeting dual-therapy mediated by indocyanine green conjugated gold nanospheres

Journal of Controlled Release : Official Journal of the Controlled Release Society
Wei LiJian You

Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) have captured much attention due to the great potential to cure malignant tumor. Nevertheless, photodynamic resistance of cancer cells has limited the further efficacy of PDT. Unfortunately, the resistance mechanism and efforts to overcome the resistance still have been rarely reported so far. Here, we report a nanosystem with specific tumor targeting for combined PDT and PTT mediated by near-infrared (NIR) light, which was established by covalently conjugating indocyanine green (ICG) and TNYL peptide onto the surface of hollow gold nanospheres (HAuNS). Our nanosystem (TNYL-ICG-HAuNS) was proved to possess significantly increased light stability, reactive oxygen species (ROS) production and photothermal effect under NIR light irradiation, thus presenting a remarkably enhanced antitumor efficacy. The up-regulation of nuclear factor erythroid 2-related factor 2 (NFE2L2, Nrf2) in cancer cells during PDT induced a significant increase of ABCG2, NQO-1 and HIF-1α expression, causing PDT resistance of the cells. Interestingly, ABCG2 expression could almost keep a normal level in the whole PDT process mediated by TNYL-ICG-HAuNS. After repeated irradiations, TNYL-ICG-HAuNS could ...Continue Reading

Citations

May 29, 2018·Angewandte Chemie·Xingshu LiJuyoung Yoon
Aug 18, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Paula García CalaviaDavid A Russell
Feb 23, 2019·Nanomedicine·Bankuru Navyatha, Seema Nara
Jul 6, 2020·Colloids and Surfaces. B, Biointerfaces·Andreea CampuSimion Astilean
Oct 23, 2019·Photodiagnosis and Photodynamic Therapy·M Ibrahim KhotDavid G Jayne
Feb 9, 2021·Frontiers in Oncology·Waleska K MartinsTayana M Tsubone
Jul 30, 2021·Bioconjugate Chemistry·Anna GraczykArkadiusz Chworos
May 1, 2020·Bioconjugate Chemistry·Xingya JiangJie Zheng

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