Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors

Frontiers in Oncology
Gaurav NayyarMitchell S Cairo

Abstract

Despite advances in the diagnostic and therapeutic modalities, the prognosis of several solid tumor malignancies remains poor. Different factors associated with solid tumors including a varied genetic signature, complex molecular signaling pathways, defective cross talk between the tumor cells and immune cells, hypoxic and immunosuppressive effects of tumor microenvironment result in a treatment resistant and metastatic phenotype. Over the past several years, immunotherapy has emerged as an attractive therapeutic option against multiple malignancies. The unique ability of natural killer (NK) cells to target cancer cells without antigen specificity makes them an ideal candidate for use against solid tumors. However, the outcomes of adoptive NK cell infusions into patients with solid tumors have been disappointing. Extensive studies have been done to investigate different strategies to improve the NK cell function, trafficking and tumor targeting. Use of cytokines and cytokine analogs has been well described and utilized to enhance the proliferation, stimulation and persistence of NK cells. Other techniques like blocking the human leukocyte antigen-killer cell receptors (KIR) interactions with anti-KIR monoclonal antibodies, prev...Continue Reading

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R HandgretingerD Neithammer
Aug 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·H J ZehM T Lotze
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Mar 1, 1996·Cancer Immunology, Immunotherapy : CII·L M WeinerM W Barth
Mar 8, 2000·The Journal of Experimental Medicine·M K KennedyJ J Peschon
May 23, 2000·Critical Reviews in Biochemistry and Molecular Biology·G L Semenza
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M J SmythS E Street
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M McCallL M Weiner
May 18, 2001·Nature·B A Ponder
Jun 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·I TakanamiM Giga
Aug 21, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A D SantinG P Parham
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Nov 2, 2001·Nature Medicine·L L Lanier
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vannary TiengAntoine Toubert
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
Mar 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roberta CastriconiAlessandro Moretta
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hak-Ling MaKyriaki Dunussi-Joannopoulos

❮ Previous
Next ❯

Citations

Mar 5, 2020·Cancer Immunology, Immunotherapy : CII·Raquel TarazonaRafael Solana
Mar 11, 2020·Frontiers in Immunology·Aviad Ben-ShmuelMira Barda-Saad
Apr 11, 2020·Cancers·Christian Sordo-BahamondeSegundo Gonzalez
Oct 17, 2019·Frontiers in Immunology·Iñigo TerrénFrancisco Borrego
Jun 4, 2020·Cellular Oncology (Dordrecht)·Jiao Wang, Sandro Matosevic
Mar 7, 2020·Frontiers in Immunology·Cai ZhangChongdeng Shi
Nov 13, 2019·Expert Opinion on Biological Therapy·A Graham PockleyGabriele Multhoff
Sep 11, 2020·Cell Biology International·Yasin BagheriMehdi Yousefi
Dec 2, 2020·International Journal of Molecular Sciences·Atsushi KuwaharaRyutaro Asano
Dec 9, 2020·Journal of Hematology & Oncology·Ahmet YilmazJianhua Yu
Feb 6, 2020·Cancer Immunology Research·Dana L Casey, Nai-Kong V Cheung
Jun 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luke Maggs, Soldano Ferrone
Jan 5, 2021·Frontiers in Immunology·Simone MantessoLucia Kučerová
Dec 25, 2019·Molecular Therapy Oncolytics·Meijun ZhengHui Yang
Oct 3, 2020·Transplantation and Cellular Therapy·Carlos E SanchezConrad Russell Y Cruz
Dec 20, 2020·International Journal of Molecular Sciences·Yoo-Jin Lee, Jongsun Kim
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·V G SubrakovaA V Taranin
May 1, 2021·Pharmaceutics·Kwang-Soo KimDong-Hyun Kim
Jul 2, 2021·Frontiers in Cell and Developmental Biology·Babak ArjmandBagher Larijani
Jul 14, 2021·Nature Genetics·Michal ShefferConstantine S Mitsiades
Jul 25, 2021·Cancer Letters·Hans RaskovIsmail Gögenur
Aug 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Annoor AwadasseidWen Zhang
Jul 30, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eimear MylodMelissa J Conroy

❮ Previous
Next ❯

Methods Mentioned

BETA
genetic modification
xenografts
xenograft
transgenic

Clinical Trials Mentioned

NCT01572493
NCT03388632
NCT01629758
NCT01489059
NCT03228667
NCT03127098
NCT03022825
NCT02384954
NCT02138734
NCT02890758

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Seminars in Immunology
Fang FangZhi-Gang Tian
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Elodie PicardaXingxing Zang
Frontiers in Immunology
Andrea Schmidts, Marcela V Maus
© 2022 Meta ULC. All rights reserved