Overcoming the acoustic diffraction limit in photoacoustic imaging by the localization of flowing absorbers

Optics Letters
Sergey VilovEmmanuel Bossy

Abstract

The resolution of photoacoustic imaging deep inside scattering media is limited by the acoustic diffraction limit. In this Letter, taking inspiration from super-resolution imaging techniques developed to beat the optical diffraction limit, we demonstrate that the localization of individual optical absorbers can provide super-resolution photoacoustic imaging well beyond the acoustic diffraction limit. As a proof-of-principle experiment, photoacoustic cross-sectional images of microfluidic channels were obtained with a 15 MHz linear capacitive micromachined ultrasonic transducer array, while absorbing beads were flown through the channels. The localization of individual absorbers allowed us to obtain a super-resolved cross-sectional image of the channels by reconstructing both the channel width and position with an accuracy better than λ/10. Given the discrete nature of endogenous absorbers such as red blood cells, or that of exogenous particular contrast agents, localization is a promising approach to push the current resolution limits of photoacoustic imaging.

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Citations

Apr 10, 2019·Light, Science & Applications·Pengfei ZhangLihong V Wang
Nov 9, 2019·Physical Review Letters·X Luís Deán-BenDaniel Razansky
Jul 26, 2019·Physics in Medicine and Biology·Xosé Luís Deán-Ben, Daniel Razansky
Mar 15, 2020·Scientific Reports·Sergey VilovEmmanuel Bossy
Jan 13, 2021·Reports on Progress in Physics·Chao TianYi Jin
Mar 1, 2021·The Journal of the Acoustical Society of America·Georges ChabouhGwennou Coupier
Jan 25, 2020·Ultrasound in Medicine & Biology·Kirsten Christensen-JeffriesRuud J G van Sloun
Oct 7, 2021·ACS Applied Materials & Interfaces·Daniil NozdriukhinXosé Luís Deán-Ben

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