Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery

Current Opinion in Chemical Engineering
Susan N Thomas, Alex Schudel

Abstract

Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K BeckenlehnerW Schiess
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S R Chary, R K Jain
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Young Jik KwonJean M J Fréchet
Mar 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sai T ReddyMelody A Swartz
Apr 5, 2008·European Journal of Immunology·Vania ManolovaMartin F Bachmann
Jul 26, 2008·Nature Nanotechnology·Yan GengDennis E Discher
Sep 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Uta WattendorfHans P Merkle
Dec 18, 2008·Pharmaceutical Research·Chien-Chi Lin, Kristi S Anseth
Jan 13, 2009·Nature Materials·Omar A AliDavid J Mooney
Feb 3, 2009·Immunity·Ramon RoozendaalMichael C Carroll
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
Aug 18, 2009·Seminars in Cell & Developmental Biology·Katarina WolfPeter Friedl
Aug 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisa M KaminskasChristopher Jh Porter
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven D Perrault, Warren C W Chan
Sep 8, 2010·Biophysical Journal·Triantafyllos StylianopoulosRakesh K Jain
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Dec 25, 2010·Biomaterials·Susan N ThomasJeffrey A Hubbell
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Cliff WongDai Fukumura
Aug 26, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karen Y DaneJeffrey A Hubbell
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christopher M JewellDarrell J Irvine
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chiara NembriniJeffrey A Hubbell
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shan LiaoTimothy P Padera
Jan 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZhuangLintao Cai
Aug 24, 2012·Science Translational Medicine·Melody A SwartzJeffrey A Hubbell
Sep 25, 2012·Nature Biotechnology·Junji KomoriEric Lagasse
Jul 3, 2013·International Journal of Nanomedicine·Qiu GuoWenGe Sun
Aug 21, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gemma M RyanChristopher J H Porter
Oct 24, 2013·Nature Materials·Darrell J IrvineGregory L Szeto
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alexandre de TittaJeffrey A Hubbell
Feb 1, 2014·Current Opinion in Organ Transplantation·Aaron D DeWardEric Lagasse

❮ Previous
Next ❯

Citations

Jan 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nathan Andrew Rohner, Susan Napier Thomas
Oct 23, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jardin LeleuxKrishnendu Roy
Oct 17, 2015·Nature Reviews. Drug Discovery·Natalie L TrevaskisChristopher J H Porter
Jan 20, 2016·Expert Review of Vaccines·Joshua J GlassRobert De Rose
Mar 2, 2016·Annual Review of Biomedical Engineering·Susan N ThomasErin E Edwards
Oct 7, 2016·Chemical Society Reviews·Yizhong ShenHong-Yuan Chen
Dec 7, 2018·Biomaterials Science·Mingming ZhangChun Wang
Jan 3, 2019·Journal of Drug Targeting·Ana Sara CordeiroMaría José Alonso
Mar 6, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Joanna Stachowska-PietkaBengt Lindholm
Jul 17, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathan Andrew RohnerSusan Napier Thomas
Mar 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu HuangXinyuan Zhu
May 17, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Eelco F J MeijerTimothy P Padera
Jun 12, 2020·Nature Reviews. Materials·Alex SchudelSusan N Thomas
Feb 9, 2019·Science·John T Wilson
Jun 12, 2020·Nature Nanotechnology·Alex SchudelSusan Napier Thomas
Nov 24, 2020·Advanced Healthcare Materials·Dinh Chuong NguyenJohn T Wilson
Dec 29, 2020·Biomaterials·David WibowoBernd H A Rehm
Jan 28, 2021·Annual Review of Medicine·Wenjing XuKathleen M Caron
Apr 24, 2020·Advanced Drug Delivery Reviews·J Daniel GriffinCory J Berkland
Jan 23, 2021·Pharmaceutics·Rebekah Omarkhail Elliott, Mei He
Jun 17, 2020·Molecular Pharmaceutics·Gracia GraciaNatalie L Trevaskis
Jul 28, 2020·Biotechnology Reports·Rudolf Ladenstein, Ekaterina Morgunova
Aug 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammad AbdallahNatalie L Trevaskis
Apr 3, 2021·Drug Delivery and Translational Research·Ana Sara CordeiroMaría José Alonso
May 9, 2021·Cellular and Molecular Life Sciences : CMLS·Xingzhou PengZhihong Zhang
May 18, 2021·Acta Pharmaceutica Sinica. B·Yongchao WangXing-Jie Liang
Aug 9, 2021·Advanced Drug Delivery Reviews·Guangna LiuGuangjun Nie
Aug 8, 2021·Advanced Drug Delivery Reviews·Yingyue DingQuanyin Hu
Apr 12, 2019·Molecular Pharmaceutics·Adam S MullisBalaji Narasimhan
Aug 5, 2020·International Journal of Pharmaceutics·Megumi Nishitani YukuyamaNádia Araci Bou-Chacra
Sep 12, 2020·Chemical Reviews·Wen-Hao Li, Yan-Mei Li
Sep 28, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V· GraciaNatalie L Trevaskis
Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade
Oct 30, 2021·ACS Nano·Bilal HussainReza Abdi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2022 Meta ULC. All rights reserved