Overdispersion in allelic counts and θ-correction in forensic genetics

Theoretical Population Biology
Torben Tvedebrink

Abstract

We present a statistical model for incorporating the extra variability in allelic counts due to subpopulation structures. In forensic genetics, this effect is modelled by the identical-by-descent parameter θ, which measures the relationship between pairs of alleles within a population relative to the relationship of alleles between populations (Weir, 2007). In our statistical approach, we demonstrate that θ may be defined as an overdispersion parameter capturing the subpopulation effects. This formulation allows derivation of maximum likelihood estimates of the allele probabilities and θ together with computation of the profile log-likelihood, confidence intervals and hypothesis testing. In order to compare our method with existing methods, we reanalysed FBI data from Budowle and Moretti (1999) with allele counts in six US subpopulations. Furthermore, we investigate properties of our methodology from simulation studies.

References

Apr 1, 1996·Genetical Research·B Rannala, J A Hartigan
Jun 1, 1997·Heredity·D J Balding, R A Nichols
May 16, 2002·Science & Justice : Journal of the Forensic Science Society·J M CurranB S Weir
Oct 3, 2002·Annual Review of Genetics·B S Weir, W G Hill
Apr 12, 2003·Theoretical Population Biology·David J Balding
Dec 16, 2003·Statistics in Medicine·Obioha C UkoumunneSusan Chinn
Nov 26, 2008·The Annals of Applied Statistics·Bruce S Weir
Apr 7, 2009·Theoretical Population Biology·Suvajit SamantaBruce S Weir
Aug 19, 2009·Nature Reviews. Genetics·Kent E Holsinger, Bruce S Weir
Sep 30, 2010·Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·Hua Zhou, Kenneth Lange

❮ Previous
Next ❯

Citations

Sep 3, 2013·Computational Statistics & Data Analysis·Hua Zhou, Yiwen Zhang
Sep 9, 2011·Forensic Science International. Genetics·Torben TvedebrinkNiels Morling
Jan 4, 2013·PloS One·Patricio S La RosaWilliam D Shannon
Jan 24, 2017·F1000Research·Malgorzata Nowicka, Mark D Robinson
Dec 29, 2016·Statistical Applications in Genetics and Molecular Biology·Mateen R Shaikh, Joseph Beyene
Sep 21, 2019·Biometrics·Yaru SongTao Wang
Nov 19, 2015·Frontiers in Microbiology·Karoline FaustJeroen Raes
Jul 21, 2017·BMC Genomics·Gaoxiang JiaGuanghua Xiao
Sep 26, 2020·American Journal of Epidemiology·Mitchell H GailJianxin Shi
May 19, 2021·Genome Biology·Ruizhu HuangMark D Robinson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Statistical Applications in Genetics and Molecular Biology
Iuliana Ionita-Laza, Nan M Laird
Biometrical Journal. Biometrische Zeitschrift
Sudhir R PaulTathagata Banerjee
Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
Hua Zhou, Kenneth Lange
The Annals of Applied Statistics
B S Weir
© 2021 Meta ULC. All rights reserved