Overexpressing lncRNA LAIR increases grain yield and regulates neighbouring gene cluster expression in rice

Nature Communications
Ying WangJinshui Yang

Abstract

Long noncoding RNAs (lncRNAs) are essential regulators of gene expression in eukaryotes. Despite increasing knowledge on the function of lncRNAs, little is known about their effects on crop yield. Here, we identify a lncRNA transcribed from the antisense strand of neighbouring gene LRK (leucine-rich repeat receptor kinase) cluster named LAIR (LRK Antisense Intergenic RNA). LAIR overexpression increases rice grain yield and upregulates the expression of several LRK genes. Additionally, chromatin immunoprecipitation assay results indicate H3K4me3 and H4K16ac are significantly enriched at the activated LRK1 genomic region. LAIR binds histone modification proteins OsMOF and OsWDR5 in rice cells, which are enriched in LRK1 gene region. Moreover, LAIR is demonstrated to bind 5' and 3' untranslated regions of LRK1 gene. Overall, this study reveals the role of lncRNA LAIR in regulating rice grain yield and lncRNAs may be useful targets for crop breeding.

References

Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D Gale, K M Devos
Nov 11, 1999·Current Biology : CB·J C Lucchesi
Mar 14, 2000·Current Opinion in Plant Biology·T Sasaki, B Burr
Dec 19, 2003·Nucleic Acids Research·Alex BatemanSean R Eddy
May 29, 2004·FEBS Letters·Gregor D GilfillanPeter B Becker
Jul 19, 2005·Genes & Development·Emily Bernstein, C David Allis
Jul 19, 2005·Molecular and Cellular Biology·Mikko TaipaleAsifa Akhtar
Dec 31, 2005·Nucleic Acids Research·Ivica LetunicPeer Bork
Jan 29, 2008·Development·Reina KomiyaKo Shimamoto
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Jul 22, 2009·Plant Biotechnology Journal·Xiaojun ZhaJinshui Yang
Apr 21, 2010·Genome Research·Tanmoy MondalChandrasekhar Kanduri
Jul 14, 2010·Molecular Cell·Sunil Jayaramaiah RajaAsifa Akhtar
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jun 23, 2012·PLoS Genetics·Kin Chung LamAsifa Akhtar
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Nov 8, 2012·Nature Structural & Molecular Biology·Sònia Guil, Manel Esteller
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
May 9, 2014·Nature Reviews. Genetics·Marjori A Matzke, Rebecca A Mosher
May 31, 2014·Molecular Cancer Research : MCR·Kenji TakahashiTushar Patel
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuqiu WangXing Wang Deng
May 2, 2015·The Plant Journal : for Cell and Molecular Biology·Scott Berry, Caroline Dean
Jan 17, 2016·Genes & Development·Jeffrey J QuinnHoward Y Chang
Mar 26, 2016·Pharmacology & Therapeutics·Mansi A ParasramkaTushar Patel
Apr 6, 2016·Current Genomics·Chi Han Li, Yangchao Chen
Jan 21, 2017·The Plant Journal : for Cell and Molecular Biology·Dong WangJian-Kang Zhu

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Citations

Jun 9, 2019·Science China. Life Sciences·Pingchuan Deng, Liang Wu
Mar 29, 2020·Plants·Ling WuMeng Xu
Jan 4, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yue LuYu Zhao
Nov 14, 2019·International Journal of Molecular Sciences·Xiaopei ZhangFafu Shen
Aug 14, 2019·Annual Review of Cell and Developmental Biology·Yu YuYueqin Chen
Apr 16, 2020·International Journal of Molecular Sciences·Hong ZhangWanquan Ji
Apr 1, 2020·Frontiers in Plant Science·Hikmet BudakHalise Busra Cagirici
Nov 26, 2020·Scientific Reports·Frédéric JehlSandrine Lagarrigue
Mar 7, 2021·Non-coding RNA·Camille Fonouni-FardeMartin Crespi
May 21, 2021·Functional & Integrative Genomics·Sailaja BhogireddyHimabindu Kudapa
May 25, 2021·Computational and Structural Biotechnology Journal·Xiangxiang MengShengjun Li
Jul 26, 2021·Trends in Plant Science·Rodrigo Siqueira Reis, Yves Poirier
Dec 24, 2021·Biochemical Society Transactions·Thomas RouléThomas Blein

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Datasets Mentioned

BETA
AP007224

Methods Mentioned

BETA
ChIRP
transgenic
immunoprecipitation
ChIP
RIP
PCR
Assay

Software Mentioned

ORF Finder
Xist

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