Overexpression and amplification of c-myc during progression of human colorectal cancer

Oncology
C F RochlitzE de Kant

Abstract

Overexpression and amplification of the c-myc oncogene occur in approximately 70 and 10% of human primary colorectal carcinomas, respectively, indicating the importance of this gene in colorectal tumorigenesis. Little, however, is known about the involvement of c-myc in the progression of colorectal cancer. We therefore determined c-myc gene expression and amplification in a group of primary tumors and metastases from patients with colorectal cancer using quantitative PCR-based tests. While the percentage of metastases overexpressing c-myc (13/26 = 50%) was in the same range as reported for primary tumors by others, gene amplification of c-myc was significantly (p = 0.001) more frequent in metastases (16/27 = 59%) compared to primary tumors (1/23 = 4%) in our series. Interestingly, in 23 metastases where both expression and amplification of c-myc could be determined, there was no correlation between gene copy number and expression level (p = 0.18; r = 0.19). We conclude that amplification but not overexpression of c-myc is related to metastatic progression of colorectal cancer and that overexpression of c-myc is driven by mechanisms other than the number of c-myc copies in the tumors studied.

Citations

Jun 9, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J SantosJ Fernández-Piqueras
Aug 2, 2001·Biochemical and Biophysical Research Communications·I TakemasaK Matsubara
Jan 7, 2014·Annals of Surgical Oncology·Keishi SugimachiKoshi Mimori
Sep 16, 2006·Genes, Chromosomes & Cancer·Honor HugoRobert G Ramsay
Feb 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sabha RasoolBhahwal Ali Shah
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Apr 17, 2020·Japanese Journal of Clinical Oncology·Weiyu PanYingyong Hou
Apr 11, 2008·Acta Biochimica Et Biophysica Sinica·Xiaoqing TianJingyuan Fang
Feb 11, 2015·Journal of the National Cancer Institute·Taewan KimCarlo M Croce
Dec 6, 2019·Biomarkers in Medicine·Hossein SadeghiReza Mirfakhraie
Dec 31, 2020·OncoTargets and Therapy·Yan LinRong Liang
Mar 7, 2021·International Journal of Molecular Sciences·Diamanto SkopelitouObul Reddy Bandapalli
Mar 27, 2021·Journal of Cell Communication and Signaling·Narges ToolabiMahmood Talkhabi
Mar 26, 2019·Journal of Proteome Research·Weili Miao, Yinsheng Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.