Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway

Journal of Virology
Yee-Joo TanWanjin Hong

Abstract

Besides genes that are homologous to proteins found in other coronaviruses, the severe acute respiratory syndrome coronavirus genome also contains nine other potential open reading frames. Previously, we have characterized the expression and cellular localization of two of these "accessory" viral proteins, 3a (previously termed U274) and 7a (previously termed U122). In this study, we further examined whether they can induce apoptosis, which has been observed clinically. We showed that the overexpression of 7a, but not of 3a or the viral structural proteins, nucleocapsid, membrane, and envelope, induces apoptosis. 7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, kidney, and liver.

References

Dec 1, 1996·Journal of Virology·B L HaagmansM C Horzinek
Apr 28, 1999·Trends in Microbiology·H Everett, G McFadden
Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
Apr 21, 2001·Cell Death and Differentiation·G N Barber
Jun 21, 2002·The Journal of General Virology·Stewart Hay, George Kannourakis
Oct 31, 2002·Nature Immunology·Chris A BenedictCarl F Ware
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Arlene R Collins
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 6, 2003·Science·Marco A MarraRachel L Roper
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jun 13, 2003·Lancet·Nirmal S Panesar
Aug 15, 2003·The Journal of General Virology·Volker ThielJohn Ziebuhr
Sep 13, 2003·BMJ : British Medical Journal·Roddy O'DonnellMichael F E Roe
Sep 13, 2003·BMJ : British Medical Journal·Anthony Barton
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Atul HumarGary A Levy
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tai-Nin ChauChing-Lung Lai
Jun 2, 2004·Journal of Medical Virology·Huimin YanGeorge F Gao

❮ Previous
Next ❯

Citations

Jul 18, 2006·Cell Biology and Toxicology·Gang ZhaoJing-Pian Peng
Jun 14, 2005·Current Opinion in Immunology·Yu Lung Lau, J S Malik Peiris
Apr 23, 2008·Current Opinion in Pulmonary Medicine·David S Hui, Paul K S Chan
Oct 16, 2007·Clinical Microbiology Reviews·Vincent C C ChengKwok Yung Yuen
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Susan R Weiss, Sonia Navas-Martin
Jan 25, 2007·Annual Review of Immunology·Jun Chen, Kanta Subbarao
May 23, 2006·Annual Review of Microbiology·Luis EnjuanesSonia Zuñiga
Feb 11, 2010·Virology Journal·Natalia VasilenkoAlexander Zakhartchouk
Nov 21, 2007·Biological Chemistry·Karen Hänel, Dieter Willbold
Mar 15, 2014·Current Opinion in Pulmonary Medicine·David S HuiAlimuddin Zumla
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wei LuBing Sun
Feb 7, 2006·FEBS Letters·Tetsuya MizutaniShigeru Morikawa
Aug 19, 2008·Biochimica Et Biophysica Acta·Zhongde YeYong Xie
Nov 30, 2007·Virus Research·Krishna NarayananShinji Makino
Sep 11, 2007·Virus Research·Yong GuoJiang Gu
Jul 21, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Youjun Feng, George F Gao
May 2, 2007·Annals of the New York Academy of Sciences·T Mizutani
Mar 30, 2007·The American Journal of Pathology·Jiang Gu, Christine Korteweg
Apr 4, 2006·Biochemical and Biophysical Research Communications·Burtram C FieldingYee-Joo Tan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.