Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis.

Plant Cell Reports
Hongchun YangLigeng Ma

Abstract

The methylation of histone 3 lysine 4 (H3K4) is essential for gene activation. Flowering Locus C (FLC), an important flowering repressor, quantitatively regulates flowering time in Arabidopsis and its expression level is coincident with H3K4 trimethylation (H3K4me3) dynamics. The methylation state of FLC chromatin is determined by the balance between methylation and demethylation, which is mediated by histone methyltransferases and demethylases, respectively. However, little is known about the role of histone demethylase(s) in FLC regulation. Here, we characterized the biochemical activity and biological function of a novel JmjC domain-containing H3K4 demethylase, JMJ15, in Arabidopsis. JMJ15, which is a member of the H3K4 demethylase JARID1 family, displayed H3K4me3 demethylase activity both in vitro and in vivo. The mutation of JMJ15 did not produce an obvious phenotype; however, overexpression JMJ15 resulted in an obvious early flowering phenotype, which was associated with the repression of FLC level and reduction in H3K4me3 at the FLC locus, resulting in increased FT expression. Our results suggest that JMJ15 is a novel H3K4 demethylase, involved in the control of flowering time by demethylating H3K4me3 at FLC chromatin wh...Continue Reading

References

Jan 1, 1994·Molecular & General Genetics : MGG·J H Clarke, C Dean
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Nov 1, 2003·Science·Yuehui HeRichard M Amasino
Aug 19, 2004·The Plant Journal : for Cell and Molecular Biology·Chris BowlerJerzy Paszkowski
Oct 1, 2004·Development·Yindee ChanvivattanaJustin Goodrich
Jan 12, 2005·Trends in Plant Science·Yuehui He, Richard M Amasino
May 3, 2005·Annual Review of Plant Biology·Sibum Sung, Richard M Amasino
Aug 17, 2005·PLoS Genetics·Janne LempeDetlef Weigel
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·J MylneC Dean
Dec 13, 2005·Current Opinion in Plant Biology·José C Reyes
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Feb 27, 2007·Cell·Robert J KloseWilliam G Kaelin
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Cell·Bing LiJerry L Workman
Mar 8, 2007·Nature Reviews. Molecular Cell Biology·Robert J Klose, Yi Zhang
Mar 14, 2007·Nature Structural & Molecular Biology·Joel C EissenbergAli Shilatifard
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 7, 2007·Nature Structural & Molecular Biology·Xiaoyu ZhangSteven E Jacobsen
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Candice C SheldonW James Peacock
May 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaofei YuYanhai Yin
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qianwen Sun, Dao-Xiu Zhou
Oct 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Filomena De LuciaCaroline Dean

❮ Previous
Next ❯

Citations

Jul 15, 2015·Molecular Genetics and Genomics : MGG·Yong HuangYing Ruan
Jul 11, 2014·Frontiers in Plant Science·Yuan ShenDao-Xiu Zhou
May 25, 2016·Molecules and Cells·Kyounghee LeePil Joon Seo
Sep 11, 2016·Current Opinion in Plant Biology·Jun XiaoDoris Wagner
Jan 1, 2016·Biologie aujourd'hui·Alexandre BerrWen-Hui Shen
May 1, 2019·The New Phytologist·Shuangzhan HuangZheng-Yi Xu
Feb 19, 2020·Journal of Experimental Botany·Atsuko Kinoshita, René Richter
Nov 30, 2019·The Plant Journal : for Cell and Molecular Biology·Shuanghe CaoXianchun Xia
Sep 29, 2019·Journal of Experimental Botany·Kai ChengMing Luo
Nov 12, 2019·Frontiers in Plant Science·Rubina JibranToshi M Foster
Dec 13, 2019·Development·Pietro CattaneoChristian S Hardtke
Oct 23, 2020·Functional & Integrative Genomics·Gaurav AgarwalRajeev K Varshney
Jan 29, 2021·Current Opinion in Plant Biology·Kaixuan HeXian Deng
Apr 24, 2021·Transgenic Research·S Selma, D Orzáez
May 25, 2021·Physiologia Plantarum·Wai-Shing YungHon-Ming Lam
May 30, 2021·Journal of Experimental Botany·Saurabh Prakash PandeyMarkus Schmid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.