Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice

Molecular and Cellular Biochemistry
Yuying ZhangChuan-Ju Liu

Abstract

The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was found to be elevated in the course of collagen-induced arthritis (CIA). ADAMTS-7 transgenic (TG) mice were more susceptible to the induction of CIA. The onset of CIA was accelerated and the arthritic severity was increased in TG mice compared to wild-type mice. The overall incidence was also significantly higher in TG mice. In addition, arthritic TG mice displayed significantly higher clinical and histological arthritis scores. The COMP degradative fragments were significantly elevated in articular cartilage and sera in CIA models of TG mice. Furthermore, the production of tumor necrosis factor-alpha and interleukin-17 was also increased in serum and draining lymph nodes of arthritic TG mice. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis, and that inhibition of ADAMTS-7 may be a potential target to ameliorate the severity of inflammatory arthritis.

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Citations

Jan 29, 2016·Journal of Cellular and Molecular Medicine·Selene Pérez-GarcíaYasmina Juarranz
Dec 24, 2015·Mediators of Inflammation·Yuying ZhangFanhua Wei
Nov 6, 2018·Expert Review of Clinical Immunology·Lina Serhal, Christopher J Edwards
Oct 23, 2019·International Journal of Molecular Medicine·Han CaiJinghe Lang
Jun 18, 2017·Scientific Reports·Eva BengtssonIsabel Gonçalves

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