Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma

Medical Oncology
Wei WangChu-Shu Ji

Abstract

Angiogenic factor with G-patch and FHA domains 1 (AGGF1) is a factor implicating in vascular differentiation and angiogenesis. Several lines of evidence indicate that aberrant expression of AGGF1 is associated with tumor initiation and progression. The aim of this study was to investigate the expression and prognostic value of AGGF1 in hepatocellular carcinoma (HCC), as well as its relationship with clinicopathological factors and tumor angiogenesis. Immunohistochemistry was performed to evaluate the expression of AGGF1 in HCC and paracarcinomatous tissues collected from 70 patients. Vascular endothelial growth factor (VEGF) and CD34 expression levels were examined in the 70 HCC tissues. Prognostic significance of tumoral AGGF1 expression was determined. Notably, AGGF1 expression was significantly higher in HCC than in surrounding non-tumor tissues (65.7 vs. 25.7 %; P < 0.001). AGGF1 expression was significantly correlated with tumoral VEGF expression and CD34-positive microvessel density. Moreover, AGGF1 expression was significantly associated with tumor size, tumor capsule, vascular invasion, Edmondson grade, alpha-fetoprotein level, and TNM stage. Kaplan-Meier survival analysis showed that high AGGF1 was correlated with redu...Continue Reading

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Citations

Apr 18, 2017·Experimental and Therapeutic Medicine·Chun LiXiaodong Gai
Mar 16, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Han-Hui YaoQiang Huang
Jan 30, 2018·Frontiers in Molecular Neuroscience·Chunqing YangYunhui Liu
Dec 16, 2019·Seminars in Cancer Biology·Monika BhardwajRavi K Amaravadi

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