Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma.

International Journal of Medical Sciences
Xiao-Long WangZhi-Jun Sun

Abstract

ATPase family AAA domain-containing protein 2 (ATAD2) is highly expressed in a variety of malignancies and can promote the proliferation of tumor cells and inhibit their differentiation. However, the expression of ATAD2 and its related mechanism in oral squamous cell carcinoma (OSCC) are still unknown. Immunohistochemical staining of ATAD2, cancer stem cells (CSCs) markers and immune checkpoint molecules was conducted on human OSCC specimens to determine the expression levels of these proteins and their correlations with the clinicopathological characteristics of ATAD2 in OSCC. Moreover, the role of ATAD2 in cell proliferation, apoptosis, migration and epithelial-mesenchymal transition (EMT) were assessed by silencing ATAD2 in vitro. Immunohistochemical analysis revealed that ATAD2 expression in OSCC tissues was markedly higher than that in adjacent dysplastic tissues and normal mucosal tissues. Overexpression of ATAD2 was related to poor overall survival in OSCC patients. In addition, the protein expression of ATAD2 was notably correlated with the expression of B7-H4, PD-L1, CMTM6, Slug and ALDH1 in human OSCC. ATAD2 knockdown arrested the cell cycle, promoted the apoptosis, and inhibited the proliferation, migration, and EMT ...Continue Reading

Citations

Mar 13, 2021·Life Sciences·Aditi NayakAnasuya Roychowdhury
Nov 17, 2021·Journal of Cancer Research and Clinical Oncology·Jie LiangBei Zhang

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Methods Mentioned

BETA
transfection
electrophoresis

Software Mentioned

Aperio Quantification
Cluster
Cutoff Finder
TreeView
CytExpert
ModFit
GEPIA
GraphPad Prism
SPSS

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