PMID: 11920460Mar 29, 2002Paper

Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

Cancer
Kentaro KatoHiroyuki Katoh

Abstract

Caveolin-1 plays a regulatory role in several signaling pathways. Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown. One hundred thirty surgical specimens of esophageal squamous cell carcinoma were immunohistochemically assessed for caveolin-1 expression by polyclonal antibody. Caveolin-1 immunoreactivity was correlated with patients' clinicopathologic parameters and outcome. Positive caveolin-1 immunostaining was detected in 58 patients (44.6%). Positive caveolin-1 immunostaining correlated positively with pathologic stage (P = 0.029), pN (P = 0.023), and pM (P = 0.018). The overall survival rate was worse in patients with caveolin-1-positive tumors than in patients with caveolin-1-negative tumors (P = 0.0215). Univariate analyses identified caveolin-1 positivity (P = 0.0238), pT (P = 0.0002), pN (P < 0.0001), pM (P = 0.0002), lymphatic invasion (P = 0.0021), and positive surgical margin (P < 0.0001) as negative prognostic predictors. Multivariate analyses indicated that pT (P = 0.0296), pN (P = 0.0003), and a positive surgical margin (P = 0.0452) were independent prognostic factors. Over-expressio...Continue Reading

References

Aug 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T Joneson, D Bar-Sagi
Oct 21, 1998·Oncogene·S L CampbellC J Der
Apr 5, 2000·The Journal of Biological Chemistry·J HulitR G Pestell
Mar 10, 2001·The American Journal of Pathology·K WiechenU Schneider
Jun 23, 2001·Annals of Surgery·J M CollardP J Kestens

❮ Previous
Next ❯

Citations

Feb 29, 2008·International Journal of Colorectal Disease·Kyongrae KimJiyoung Park
Jul 20, 2006·Acta Neuropathologica·V BarresiG Barresi
Apr 28, 2005·Journal of Cancer Research and Clinical Oncology·Ken NakataniShigeyuki Fujita
Mar 17, 2006·Breast Cancer Research and Treatment·Socorro María Rodríguez PinillaJosé Palacios
May 29, 2008·Cancer Metastasis Reviews·Jacky G GoetzIvan R Nabi
Jan 23, 2009·Journal of Molecular Histology·Cristiana Pistol TanaseMihail Eugen Hinescu
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki
Oct 22, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seong-Ho YooDoo Hyun Chung
Nov 10, 2010·Journal of Proteome Research·J Patrick Murphy, Devanand M Pinto
Jul 8, 2009·Prostate Cancer and Prostatic Diseases·T C ThompsonS Park
Feb 23, 2005·Prostate Cancer and Prostatic Diseases·L LiT C Thompson
Apr 24, 2004·The American Journal of Surgical Pathology·Lisa M YerianJohn Hart
Feb 28, 2008·The Cancer Journal·Deborah A Bradley, Maha Hussain
Apr 17, 2009·Journal of Gastroenterology and Hepatology·Judy Wai Ping YamIrene Oi-Lin Ng
Sep 10, 2009·Molecular Cancer Research : MCR·Masami WatanabeTimothy C Thompson
Mar 19, 2005·The Journal of Clinical Investigation·Liyan ZhuangMichael R Freeman
Jan 20, 2011·Annals of Surgical Oncology·Da-Tian BauRu-Yin Tsai
Aug 14, 2012·Genetics and Molecular Biology·Hongyun GaoMingsong Wang
Mar 5, 2011·International Journal of Oncology·Aniruddha SenguptaVicente Notario
Oct 26, 2005·Breast Cancer Research and Treatment·Gert G Van den EyndenKenneth L van Golen
May 17, 2014·Pathology, Research and Practice·Fei HanXianghua Yi
Nov 15, 2011·Annual Review of Pathology·Federica SotgiaMichael P Lisanti
Mar 8, 2014·World Journal of Gastroenterology : WJG·Julian SwierczynskiTomasz Sledzinski
Oct 20, 2015·Journal of Cellular Physiology·Pierangela TottaFilippo Acconcia
Nov 6, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Craig ReynoldsLina Asmar
Sep 9, 2015·Biomedical Journal·Christophe Lamaze, Stéphanie Torrino
Jul 12, 2011·European Urology·Maxine SunPierre I Karakiewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.