Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer

International Journal of Cancer. Journal International Du Cancer
Liping YeLibing Song

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high proliferative and metastatic phenotypes. CDCA7, a new member of the cell division cycle associated family of genes, is involved in embryonic development and dysregulated in various types of human cancer. However, the biological role and molecular mechanism of CDCA7 in TNBC have not been defined. Herein, we found that CDCA7 was preferentially and markedly expressed in TNBC cell lines and tissues. High expression of CDCA7 was associated with metastatic relapse status and predicted poorer disease-free survival in patients with TNBC. We observed that CDCA7 silencing in TNBC cell lines effectively impaired cell proliferation, invasion and migration in vitro. Importantly, depletion of CDCA7 strongly reduced the tumorigenicity and distant colonization capacities of TNBC cells in vivo. Furthermore, CDCA7 increased the expression of EZH2, a marker of aggressive breast cancer that is involved in tumor progression, by enhancing the transcriptional activity of its promoter. This increase in EZH2 expression was essential for the CDCA7-mediated effects on TNBC progression. Finally, our immunohistochemical analysis revealed that the CDCA7/EZH2 axis ...Continue Reading

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Citations

Jan 23, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiao WangWei-Qiang Gao
Feb 24, 2021·Molecular Cancer Research : MCR·Maria Francesca BaiettiAnna A Sablina
Oct 7, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johannes BrägelmannJusto Lorenzo Bermejo
Jun 25, 2021·The Journal of International Medical Research·Xiquan ZhangChuyan Yang

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