Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease

Psychiatry Investigation
Hyeran KimDoh Kwan Kim

Abstract

Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical manifestations in AD. We examined the lymphocyte expression of cell cycle proteins in AD patients, dementia controls (DC), and normal controls (NC). One-hundred seventeen subjects (36 AD, 31 DC, and 50 NC) were recruited. The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes. Cell cycle protein expression in the three groups was compared after adjusting for age and sex. The levels of cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were significantly higher in AD patients than in the NC subjects. The DC group manifested intermediate levels of cell cycle proteins compared with the AD patients and the NC subjects. The present study indicates that cell cycle proteins are upregulated in the peripheral lymphocytes of AD patients. Cell cycle dysregulation in peripheral lymphocytes may present a promising starting point for identifying peripheral biomarkers of AD.

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Citations

Dec 23, 2016·Journal of Proteome Research·Raffaele FerrariClaudia Manzoni
Jul 22, 2017·Neuroscience·Nadia El KadmiriSellama Nadifi
May 23, 2020·International Journal of Molecular Sciences·Juan Luis Fernández-MartínezAndrzej Kloczkowski
Apr 18, 2019·Molecular Neurobiology·Kelly N H NudelmanAndrew J Saykin
Feb 19, 2021·Neuroscience Letters·Key-Hwan LimJae-Yeol Joo
Jul 25, 2021·International Journal of Molecular Sciences·Chiara MagriMassimo Gennarelli

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Methods Mentioned

BETA
protein assay
biopsies

Software Mentioned

SAS
Image Lab

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