Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus

The Journal of Immunology : Official Journal of the American Association of Immunologists
Evelyne Jouvin-MarchePatrice N Marche

Abstract

Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage.

References

Oct 1, 1992·Protein Science : a Publication of the Protein Society·K M PanS B Prusiner
May 14, 1992·Nature·T J MolinaA Veillette
Jan 1, 1990·Annals of the New York Academy of Sciences·O A Lukasewycz, J R Prohaska
Jan 1, 1990·Advances in Experimental Medicine and Biology·J R Prohaska, O A Lukasewycz
Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
May 1, 1987·The American Journal of Clinical Nutrition·L D KollerJ R Williams
Aug 1, 1986·DNA·H A KretzschmarS J Dearmond
Aug 1, 1995·Current Opinion in Neurology·P Parchi, P Gambetti
Feb 1, 1996·Journal of Virology·C I LasmézasD Dormont
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y XuD Baltimore
Dec 31, 1997·Nature·D R BrownH Kretzschmar
Jun 4, 1998·Biochemistry·J StöckelS B Prusiner
Dec 16, 1998·Immunological Reviews·S ChanD Mathis
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J RaeberC Weissmann
Jun 8, 1999·Annual Review of Immunology·E SebzdaP S Ohashi
Jul 8, 1999·The Journal of Nutrition·M M PeñaD J Thiele
Aug 11, 1999·Seminars in Immunology·A C HaydayE S Hoffman
Apr 8, 2000·Free Radical Biology & Medicine·Y Pan, G Loo
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Lemaire-VieilleJ Y Cesbron
May 29, 2000·The Journal of Nutrition·Z L Huang, M L Failla
Jun 30, 2000·Biochemical and Biophysical Research Communications·B S WongM S Sy
Sep 16, 2000·Science·S Mouillet-RichardO Kellermann
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T LiuM S Sy
Sep 26, 2001·The Journal of Biological Chemistry·C Spielhaupter, H M Schätzl
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshinori NakayamaSteven F Ziegler
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marco PrinzAdriano Aguzzi
Jun 1, 2002·Current Opinion in Chemical Biology·Sylvain Lehmann
Jun 25, 2003·Toxicology·Lisa M Gaetke, Ching Kuang Chow
Aug 12, 2003·Trends in Immunology·David A Padgett, Ronald Glaser
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Benoît SchneiderOdile Kellermann
Sep 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Claudia A O StuermerHelmut Plattner

❮ Previous
Next ❯

Citations

Dec 13, 2007·Neuroimmunomodulation·Eugênia Terra-GranadoSuse Dayse Silva-Barbosa
Feb 25, 2009·Annals of the New York Academy of Sciences·Daniella Arêas Mendes-da-CruzWilson Savino
Jul 5, 2012·PloS One·Marko SnajderNataša Poklar Ulrih
Aug 21, 2013·Molecular Neurobiology·Franc LlorensJosé Antonio del Río
May 4, 2013·Journal of Neurochemistry·Franc LlorensJosé A del Río
Oct 27, 2011·International Journal of Alzheimer's Disease·Nina L Salazar-Weber, Jeffrey P Smith
Aug 19, 2010·Cellular and Molecular Life Sciences : CMLS·Catherine Aude-GarciaEvelyne Jouvin-Marche
Dec 5, 2015·Frontiers in Immunology·Wilson SavinoVinicius Cotta-de-Almeida
Apr 1, 2007·Prion·Andrew D SteeleAdriano Aguzzi
Jul 31, 2007·Acta Neurologica Scandinavica·W HuO Stüve
Feb 18, 2011·Journal of Cellular Biochemistry·Thorsten KucziusReinhard Kelsch
Jun 17, 2009·FEBS Letters·Mario NuvoloneMathias Heikenwalder
Oct 20, 2006·Nature·Byron Caughey, Gerald S Baron
Apr 5, 2017·Frontiers in Molecular Neuroscience·Rafael Linden
Aug 21, 2007·Journal of the Neurological Sciences·Wei HuOlaf Stüve

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.