Abstract
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a newly characterized oncoprotein involved in a variety of malignant tumors. However, its expression pattern and biological functions in clear cell renal cell carcinoma (ccRCC) remain unclear. In the present study, our findings demonstrated that expressions of CIP2A mRNA and protein in ccRCC tissues and cell lines were significantly higher than those in paired normal renal tissues or normal renal tubular epithelial cells (P<0.05). High CIP2A level was closely correlated with T stage (P=0.001), tumor size (P=0.009), lymph node metastasis (P=0.014), vascular invasion (P=0.018) and high Snail expression (P<0.001). Additionally, ccRCC patients with high CIP2A expression had significantly shorter overall survival (OS, P<0.001) and disease-free survival (DFS, P<0.001) when compared with patients with the low expression of CIP2A. On Cox multivariate analysis, CIP2A overexpression was an independent and significant prognostic factor for OS (P=0.010) and DFS (P=0.004). Furthermore, knockdown of the CIP2A expression significantly reduced ccRCC cell invasion, with decreased Snail and Vimentin expression, and increased E-cadherin expression. Taken together, our data identified CIP2A ...Continue Reading
References
Apr 26, 2005·Clinics in Laboratory Medicine·Christine M Lohse, John C Cheville
Jul 17, 2007·Cell·Melissa R JunttilaJukka Westermarck
Feb 8, 2008·Cell Cycle·Melissa R Junttila, Jukka Westermarck
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christophe CômeJukka Westermarck
Jan 14, 2010·Cancer Research·Allan J PantuckMatthew B Rettig
May 27, 2010·PloS One·Han W TunJohn A Copland
Sep 16, 2010·Annals of Surgical Oncology·Qian-Ze DongEn-Hua Wang
Oct 16, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takeo KosakaMototsugu Oya
Apr 14, 2011·Nature Reviews. Urology·Grant D StewartDana Faratian
Aug 3, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shuji MikamiYasunori Okada
Oct 25, 2011·Gynecologic Oncology·Yan LiShixuan Wang
Nov 15, 2011·British Journal of Cancer·J RenZ Xu
Jan 18, 2012·Oncogene·M NiemeläJ Westermarck
Feb 14, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hao-Wei TengKuen-Feng Chen
Aug 1, 2012·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Hui HeYongfeng Liu
Apr 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei WangHong-Yong Cao
Mar 13, 2014·Annals of Surgical Oncology·Le XuJiejie Xu
Dec 3, 2014·Cancer Letters·Yi WuPeng-Sheng Zheng
Citations
Jul 26, 2018·PloS One·Min TangYe Tian
Sep 7, 2019·Medicine·Xiaolin WangShiwu Wu
Feb 29, 2020·Cardiovascular Research·Kashif Rafiq ZahidDeming Gou
Jun 15, 2017·Oncotarget·Zhong-Yan LiuYue-Zu Fan
Apr 8, 2017·Oncotarget·Peng ZhangYi Gao
Dec 10, 2017·Oncotarget·Yi XuYunfu Cui
Oct 6, 2017·Oncotarget·Hardik R ModyRajgopal Govindarajan
Dec 1, 2018·Molecular Oncology·Nerina DenaroCristiana Lo Nigro
Jul 18, 2018·International Journal of Oncology·Ming-Tai HuXiao-Qing Jiang
Sep 27, 2018·Oncology Letters·Xinxin YuQiongzhu Dong
Sep 20, 2019·Disease Markers·Yanhong LiFang Fang
Jan 6, 2021·Journal of Molecular Neuroscience : MN·Dezheng GaoFeng Li
Apr 24, 2021·Brain Research Bulletin·Zhixing XuJun Pu