PMID: 2112250Jun 1, 1990Paper

Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span

Proceedings of the National Academy of Sciences of the United States of America
N O SetoG M Tener

Abstract

Aging and disease processes may be due to deleterious and irreversible changes produced by free radical reactions. The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) performs a protective function by scavenging superoxide radicals. The Cu-Zn SOD gene (Sod) cloned from Drosophila melanogaster was introduced via P element-mediated transformation into the germ line. Homozygous lines carrying additional copies of the Sod gene were recovered and characterized. Increases in Sod transcripts and enzyme activity were observed in the transformed lines, indicating that all of the sequence information required for gene expression is contained on the inserted gene fragment. The effects of additional SOD on oxygen free radical metabolism and longevity were investigated. Additional SOD did not markedly affect oxygen metabolism or longevity.

References

Aug 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S HayashiG M Tener
Sep 8, 1978·Science·I Fridovich
Sep 1, 1979·Archives of Biochemistry and Biophysics·H M Hassan, I Fridovich
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P PhillipsA J Hilliker
Apr 1, 1986·Biochemical Genetics·J D Graf, F J Ayala
Jul 10, 1987·Nucleic Acids Research·N O SetoG M Tener
Dec 23, 1987·Nucleic Acids Research·N O SetoG M Tener
Sep 1, 1985·Archives of Biochemistry and Biophysics·Y M LeeF J Ayala
Feb 1, 1980·Cell·E A FyrbergK L Kindle
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P R LangerD C Ward
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y M LeeF J Ayala
Oct 22, 1982·Science·G M Rubin, A C Spradling
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M TolmasoffR G Cutler
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Harman
Jan 1, 1980·Experimental Gerontology·J MiquelJ E Johnson

❮ Previous
Next ❯

Citations

Jan 1, 1995·Archives of Insect Biochemistry and Physiology·G W Felton, C B Summers
Oct 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Tower
Nov 5, 1999·Archives of Biochemistry and Biophysics·R J MockettR S Sohal
Feb 1, 1993·Aging : Clinical and Experimental Research·R S Sohal
Oct 1, 1991·Mechanisms of Ageing and Development·R S Sohal
Jul 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·E Le BourgP Bullens
Jun 1, 1992·Progress in Neurobiology·C P LeBel, S C Bondy
Jan 1, 1993·Experimental Gerontology·M VertechyM T Ramacci
Jan 1, 1995·Experimental Gerontology·M DurusoyA N Bozcuk
Sep 1, 1994·Free Radical Biology & Medicine·H R Warner
Sep 1, 1992·Mutation Research·J E FlemingA Niedzwiecki
Sep 1, 1992·Mutation Research·R S Sohal, U T Brunk
May 8, 2004·Mechanisms of Ageing and Development·Jingtao SunJohn Tower
Sep 16, 2000·Mechanisms of Ageing and Development·J Tower
May 12, 2001·Mechanisms of Ageing and Development·G L Boulianne
Dec 10, 2002·Mechanisms of Ageing and Development·Toshiro AigakiTakashi Matsuo
Jan 19, 2000·Neurobiology of Aging·V I KlichkoW C Orr
Feb 13, 2003·Experimental Gerontology·William C Orr, Rajindar S Sohal
Jan 1, 1997·Experimental Gerontology·D E Harrison, T H Roderick
Nov 1, 1996·Experimental Gerontology·G L Da Cunha, A K de Oliveira
Oct 26, 1999·Experimental Gerontology·M R Rose
Jun 28, 2002·Free Radical Biology & Medicine·Rajindar S Sohal
Sep 5, 2002·Free Radical Biology & Medicine·Rajindar S SohalWilliam C Orr
Oct 26, 2002·Free Radical Biology & Medicine·Gustavo Barja
Jan 11, 2003·Free Radical Biology & Medicine·Robin J MockettRajindar S Sohal
Jul 29, 2003·Aging Cell·Tamara R GoldenSimon Melov
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P L Larsen
Sep 24, 2008·The Journal of Biological Chemistry·Susan K LeganWilliam C Orr
Mar 14, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sumino YanaseNaoaki Ishii
Jan 1, 1991·Annals of the New York Academy of Sciences·R G Cutler
Nov 21, 1992·Annals of the New York Academy of Sciences·R S Sohal, W C Orr
Feb 3, 1999·Annals of the New York Academy of Sciences·G Barja
Jan 13, 2005·Genome Génome / Conseil National De Recherches Canada·R C WoodruffA J Hilliker
Aug 18, 2012·Journal of Toxicology·Andrew D Johnston, Paul R Ebert
Sep 12, 2012·Oxidative Medicine and Cellular Longevity·Patricia BackFilip Matthijssens
Dec 29, 2000·Aging : Clinical and Experimental Research·G Barja
Jun 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robin J Mockett, Amber C Nobles
Jul 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·David W Walker, Seymour Benzer
Jul 1, 1997·Age·M A Pahlavani, H Van Remmen

❮ Previous
Next ❯

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