Overexpression of CXCL3 can enhance the oncogenic potential of prostate cancer

International Urology and Nephrology
Shi-Liang GuiWei-Qun Wang

Abstract

CXCL3 and its receptor CXCR2 were considered to play particularly important roles in the progression of malignancies. However, the investigations about CXCL3/CXCR2 axis in prostate cancer have been poorly involved. Herein we firstly reported our studies on the expression and biological roles of CXCL3 and CXCR2 in prostate cancer. Expression levels of CXCL3 and CXCR2 in prostate cancer cell lines (PC-3, DU145 and LNCaP), immortalized prostate stromal cell line (WPMY-1) and immortalized prostate epithelial cell line (RWPE-1) were investigated by RT-PCR, ELISA and western blot, whereas expression levels of CXCL3 in a prostate tissue microarray were detected by immunohistochemistry. Cell counting kit-8 and transwell assays were, respectively, utilized to determine the effects of exogenous CXCL3 on the cell proliferation and migration. We further examined whether CXCL3 could regulate the expression of genes correlated with prostate tumorigenesis by RT- PCR. Elevated expression of CXCR2 was detected in DU145, LNCaP and RWPE-1. Moreover, high-level CXCL3 can be secreted by PC-3 and RWPE-1, and CXCL3 protein expression level in tissue microarray is concordant with prostate cancer metastasis. Exogenous CXCL3 does not contribute to proli...Continue Reading

References

May 18, 1999·The American Journal of Pathology·B B MooreR M Strieter
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine MurphyDavid J J Waugh
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier MestasRobert M Strieter
Nov 25, 2006·Nature Reviews. Immunology·Alberto MantovaniMassimo Locati
Nov 30, 2007·Endocrine-related Cancer·Ivan BiècheGwendal Lazennec
Mar 6, 2008·Neoplasia : an International Journal for Oncology Research·Lesa A BegleyJill A Macoska
May 22, 2008·Genome Biology·Stephanie Carter, Karen H Vousden
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Weiqun WangRunsheng Li
May 2, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chao-Jie WangXiao-Feng Sun
Jul 18, 2009·International Journal of Cancer. Journal International Du Cancer·Shailesh SinghJames W Lillard
Mar 12, 2011·Current Pharmaceutical Design·Andrea BissoGiannino Del Sal
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefano Farioli-VecchioliFelice Tirone
Jan 22, 2013·The Prostate·Roberto BenelliNicoletta Ferrari
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 23, 2013·Asian Journal of Andrology·Shan-Cheng RenYing-Hao Sun
Mar 13, 2014·Current Cancer Drug Targets·Amanda Lay Pin SeeYoon Pin Lim
Aug 20, 2014·Nature Reviews. Urology·Angela N FloresLaure Marignol

❮ Previous
Next ❯

Citations

Jun 19, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Bao-Xinzi LiuHai-Bo Cheng
Jan 15, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jie RenRong Zhou
Nov 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Xianyuan LuoJiaren Xu
Jan 29, 2019·Frontiers in Neuroscience·Qianru HeFei Ding
Apr 28, 2020·BioMed Research International·Kaisheng LiuXiao Wang
Feb 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ji Min ShinChu Won Nho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.