Overexpression of CXCR1/CXCR2 on mesenchymal stromal cells may be an effective treatment for acute myocardial infarction

Cytotherapy
Jianzhong XuZhaofang Yin

Abstract

Bone marrow (BM)-derived mesenchymal stromal cells (MSC) participate in myocardial repair following myocardial infarction (MI). However, their reparative capability is limited, partly because of poor homing abilities. MI is associated with an inflammatory reaction. Interleukin-8 (IL-8) appears to have a fundamental role in regulating neutrophil localization in ischemic tissues through binding CXCR1/CXCR2 receptors, which show major expression on neutrophils. We hypothesize that the application of IL-8 will enhance the recruitment of overexpressing CXCR1/CXCR2 MSC to sites of degenerated tissue of myocardium, decreasing the ischemic region and improving cardiac function.

References

Jul 1, 1997·Journal of the American College of Cardiology·N MarxA Schömig
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Sima T TarzamiJoan W Berman
Jul 5, 2005·Journal of Molecular and Cellular Cardiology·S VanderveldeM C Harmsen
Jan 9, 2007·Cardiovascular Research·Susanne VanderveldeMartin C Harmsen
May 15, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ming ZhangMarc S Penn
Jan 19, 2008·Journal of Molecular and Cellular Cardiology·Dongsheng ZhangYigang Wang
Feb 7, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhaokang ChengDeling Kong

❮ Previous
Next ❯

Citations

Sep 11, 2010·Advanced Drug Delivery Reviews·Christopher D Porada, Graça Almeida-Porada
Nov 26, 2009·Cytotherapy·Richard O Cannon
Oct 28, 2011·Clinical and Translational Science·Lauren S ShermanPranela Rameshwar
Jul 1, 2011·Journal of Cardiovascular Disease Research·Ian B Copland
Feb 14, 2020·Journal of Cellular Physiology·Che WangQingman Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.