Overexpression of cyclin D1 is associated with poor survival in epithelial ovarian cancer

Oncology
Federica BarbieriAngela Alama

Abstract

In order to assess the prognostic role of the cell-cycle regulator cyclin D1 in epithelial ovarian cancer, 70 patients have been studied during an observation period of 8 years. The cyclin D1 protein content was analyzed by Western blotting, and classed as negative, positive and highly positive by densitometric scanning. The relationship between cyclin D1 expression and clinicopathological variables was determined. Univariate and multivariate survival analyses were also carried out. Patients with highly positive cyclin D1 tumors had shorter overall survival than patients with positive cyclin D1 (median survival 31 vs. 49 months; p = 0.058). Furthermore, in patients with stage III/IV tumors and residual disease greater than 2 cm, cyclin D1 expression significantly influenced clinical outcome (p = 0.047 and 0.040, respectively). In the Cox's regression model, cyclin D1 expression and residual disease were identified as the most important predictors of survival (p = 0.016 and 0.002, respectively). In patients with high cyclin D1 expression and residual disease after debulking surgery greater than 2 cm, the relative risks of death were to 2.48 and 3.7, respectively, compared to their correspondent counterparts. The overexpression o...Continue Reading

Citations

Jan 12, 2012·Molecular BioSystems·Daniele VergaraMichele Maffia
Oct 24, 2009·The Journal of Biological Chemistry·Ping LaPhyllis A Dennery
Mar 9, 2006·Hematology·Salah ArefA Metwaly
Aug 19, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D S SuhJ Y Kim
Feb 27, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E J Nam, Y T Kim
Dec 15, 2010·International Journal of Molecular Sciences·Wei LiLing-Yun Zhai
Jun 21, 2014·BioMed Research International·Sankar PajaniradjeRukkumani Rajagopalan
Jan 28, 2016·Journal of Molecular Histology·Mehmet KanterBetül Kanter
Jul 4, 2008·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Mar 27, 2007·The Journal of Molecular Diagnostics : JMD·Irene Y CheungNai-Kong V Cheung
Oct 10, 2013·Journal of Cellular Physiology·Sabita N Saldanha, Trygve O Tollefsbol
Jun 15, 2011·The Biochemical Journal·Maria V BarbolinaM Sharon Stack
Nov 21, 2007·Cellular Signalling·Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Aug 28, 2007·Journal of Pharmacological Sciences·Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Mar 1, 2011·Experimental and Therapeutic Medicine·Tomoko HashimotoTadao Tanaka
May 22, 2019·Molecular Genetics & Genomic Medicine·Shiva Gholizadeh-Ghaleh AzizMaryam Pashaiasl
Oct 19, 2006·The Journal of Biological Chemistry·Fumi Takahashi-YanagaToshiyuki Sasaguri
Mar 25, 2006·Future Oncology·Sabarni K Chatterjee, Bruce R Zetter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
V MasciulloS Mancuso
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Anish BaliSusan M Henshall
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
C-H ChenS-N Chow
© 2022 Meta ULC. All rights reserved