Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction

PloS One
Xiao ChenBing Li

Abstract

Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases. Many studies have demonstrated that heme oxygenase-1 (HO-1) is involved in diverse biological processes as a cytoprotective molecule, including anti-inflammatory, anti-oxidant, anti-apoptotic, antiproliferative, and immunomodulatory effects. However, the mechanisms of HO-1 prevention in renal interstitial fibrosis remain unknown. In this study, HO-1 transgenic (TG) mice were employed to investigate the effect of HO-1 on renal fibrosis using a unilateral ureter obstruction (UUO) model and to explore the potential mechanisms. We found that HO-1 was adaptively upregulated in kidneys of both TG and wild type (WT) mice after UUO. The levels of HO-1 mRNA and protein were increased in TG mice compared with WT mice under normal conditions. HO-1 expression was further enhanced after UUO and remained high during the entire experimental process. Renal interstitial fibrosis in the TG group was significantly attenuated compared with that in the WT group after UUO. Moreover, overexpression of HO-1 inhibited the loss of peritubular capillaries. In addition, UUO-induced activation and proliferation of myofibroblasts were suppressed by HO-1 overexpre...Continue Reading

References

Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Oct 11, 2001·American Journal of Physiology. Renal Physiology·D P BasileJ L Osborn
Mar 5, 2002·Nature Medicine·Tzong-Shyuan Lee, Lee-Young Chau
Nov 6, 2002·Annals of Internal Medicine·Matthew L Esson, Robert W Schrier
Nov 19, 2003·Life Sciences·Yeong-Hau H LienArnold L Silva
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Wei MuRichard J Johnson
Apr 7, 2006·Journal of the American Society of Nephrology : JASN·Jin Hyun KimSe-Ho Chang
May 23, 2008·Journal of the American Society of Nephrology : JASN·Jeong-Hae KieNathalie Hill-Kapturczak
Nov 5, 2008·The Journal of Clinical Investigation·Sharon D RicardoAllison A Eddy
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Weichun HeYouhua Liu
Jun 23, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Ben J WuRoland Stocker
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shuei-Liong LinJeremy S Duffield
Apr 24, 2010·Journal of Inflammation·María T GrandeJosé M López-Novoa
May 4, 2010·Nature Medicine·Li YangJoseph V Bonventre
Jul 14, 2010·Seminars in Nephrology·Madeleine A VernonJeremy Hughes
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Michael Zeisberg, Eric G Neilson
Dec 24, 2010·PloS One·Matheus Correa-CostaNiels O S Câmara
Feb 4, 2011·Journal of the American Society of Nephrology : JASN·Jeremy S Duffield
Dec 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shu-min SongBing Li
Mar 3, 2012·Journal of the American Society of Nephrology : JASN·Claudia SchrimpfJeremy S Duffield
Mar 15, 2012·Nature Communications·Alfiya AkhmetshinaJörg H W Distler
Oct 12, 2012·American Journal of Nephrology·Lili LiuSheng Chen
Oct 26, 2012·The Journal of Pathology·Takahisa KawakamiJeremy S Duffield
Dec 1, 2012·Current Opinion in Rheumatology·Cécile Fligny, Jeremy S Duffield
Jan 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shuyu RenJeremy S Duffield
Mar 16, 2013·Journal of the American Society of Nephrology : JASN·Yujiro KidaJeremy S Duffield
Nov 28, 2013·Current Opinion in Nephrology and Hypertension·Karl A Nath
May 23, 2014·Cardiorenal Medicine·Frederic T BillingsMias Pretorius
Nov 18, 2014·Nephron. Experimental Nephrology·Rui CuiBing Li

❮ Previous
Next ❯

Citations

Feb 1, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Subhashini BolisettyAnupam Agarwal
Mar 7, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tsung-Chih TsengShiang-Jong Tzeng
Jul 6, 2018·Journal of Cellular and Molecular Medicine·Qian ZhangZhe Jian
Sep 2, 2016·American Journal of Physiology. Renal Physiology·Haranatha R PottetiSekhar P Reddy
Oct 21, 2016·American Journal of Physiology. Renal Physiology·Olga Ruiz-AndresAlberto Ortiz
Oct 23, 2019·The Journal of International Medical Research·Li XingXu Gao
Dec 21, 2016·Clinical Kidney Journal·Roser GuiterasJosep M Cruzado
May 17, 2019·Journal of Toxicologic Pathology·Ayaka SasakiKazuhiko Suzuki
Apr 15, 2017·Cell Stress & Chaperones·Natalia ChebotarevaEvgeniy Shilov
May 27, 2017·BioMed Research International·Xuejiao SunYu Li
Nov 5, 2020·Human & Experimental Toxicology·Hemalatha RamamoorthyBina Isaac
Jan 10, 2021·Antioxidants·Maria G Detsika, Elias A Lianos
Mar 7, 2021·International Journal of Molecular Sciences·Anne GrunenwaldMarie Frimat
Apr 22, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yi ZuoSuxian Zhou
May 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mi-Gyeong GwonKwan-Kyu Park

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Methods Mentioned

BETA
transgenic
Assay
PCR
Protein Assay
light microscopy
ELISA

Software Mentioned

SPSS
NIS
Elements

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