Overexpression of HER2/neu as a Prognostic Value in Iranian Women With Early Stage Breast Cancer; A Single Institute Study

Iranian Red Crescent Medical Journal
Hanifeh Mirtavoos MahyariNegin Khosravi

Abstract

Patients with early stage breast cancer with same treatment strategy can have markedly different outcomes. Human epidermal growth factor receptor 2 (HER2/nue) gene amplification or the subsequent overexpression of protein has been proved to be associated with patient's outcome and response to anthracyclins-based regimens. This study assessed prognostic value of HER2/nue marker in patients with early stage breast cancer who received adjuvant chemotherapy with anthracyclins-based regimens. Fifty tissue samples from patients with primary breast cancer of moderate risk receiving sequential adjuvant chemotherapy with anthracyclins-based regimens were assessed to evaluate HER2/nue gene status (quantified by Immunohistochemistry and fluorescence in situ hybridization) retrospectively. Besides, correlation of HER2/neu with patients' characteristics and outcome was studied. HER2/neu amplification was identified in 19 (38%) of 50 patients. No significant difference regarding HER2/neu status was seen in clinic pathological characteristics of patients. Although Progression Free Survival (PFS) was shorter in HER2 overexpressed group, but uni/multivariate analysis adjusted for HER2 overexpression, nodal involvement, hormone receptor status, ...Continue Reading

References

Oct 1, 1998·The New England Journal of Medicine·G N Hortobagyi
Nov 6, 2001·Oncology·M PiccartD Larsimont
May 22, 2002·Clinical Breast Cancer·Peter C DubskyRaimund Jakesz
May 19, 2006·The New England Journal of Medicine·Kathleen I PritchardUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 13, 2007·Advances in Experimental Medicine and Biology·Ana Maria Gonzalez-AnguloGabriel N Hortobagyi
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathleen I PritchardBindi Dhesy-Thind
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Madhuri Kakarala, Max S Wicha
Jan 1, 2007·Archives of Pathology & Laboratory Medicine·Antonio C WolffUNKNOWN American Society of Clinical Oncology/College of American Pathologists
Jul 22, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raymond TubbsDaniel F Hayes
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jan C BraseMathias C Gehrmann
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AebiUNKNOWN ESMO Guidelines Working Group
Dec 3, 2010·The New England Journal of Medicine·Miguel MartínUNKNOWN GEICAM 9805 Investigators
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 10, 2012·World Journal of Surgical Oncology·Hyung Seok ParkSang Seol Jung
Jul 3, 2013·Journal of Thoracic Disease·Hussein A AssiNagi S El Saghir
Aug 1, 2013·Bulletin du cancer·Anthony GonçalvesJean-Philippe Spano

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