Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer

Oncology Reports
Yuandong XuXuehu Xu

Abstract

HES6 is a member of the hairy-enhancer of the split homolog family, which has been implicated in oncogenesis and cancer progression in a variety of human cancers, including prostate and breast cancer. However, its clinical significance and biological role in colorectal cancer (CRC) remain unclear. In the present study, the expression of HES6 was significantly upregulated in CRC cell lines and CRC tissues at both the mRNA and protein levels. The present study also reported high expression of HES6 in 138/213 (64.8%) paraffin-embedded archived CRC specimens. HES6 expression was significantly correlated with T classification (P<0.001), N classification (P=0.020), and distant metastasis (P<0.001). Patients with higher HES6 expression levels exhibited a reduced overall survival (P<0.001). In addition, a multivariate analysis revealed that the expression of HES6 may be a novel prognostic marker for the survival of patients with CRC. Furthermore, the present study demonstrated that ectopic expression of HES6 enhanced the migration and invasive abilities of CRC cells. These abilities were significantly inhibited upon knockdown of endogenous HES6 expression by specific short hairpin RNAs. Additionally, the present study reported that the...Continue Reading

Citations

Jun 25, 2020·Cancers·Kirsten Strømme Kierulf-VieiraEinar Osland Vik-Mo
Feb 12, 2021·Genes & Diseases·Mikhail PakvasaRussell R Reid
Jul 3, 2021·Mathematical Biosciences and Engineering : MBE·Li-Sha PanHao Liang

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Methods Mentioned

BETA
PCR
protein assay
xenograft
surgical resection

Software Mentioned

GSEA
SPSS
GraphPad Prism

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