Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.

Biochimica Et Biophysica Acta
Qing ZhuNingjun Li

Abstract

Hypoxia inducible factor (HIF)-1α-mediated gene activation in the renal medulla in response to high salt intake plays an important role in the control of salt sensitivity of blood pressure. High salt-induced activation of HIF-1α in the renal medulla is blunted in Dahl S rats. The present study determined whether the impairment of the renal medullary HIF-1α pathway was responsible for salt sensitive hypertension in Dahl S rats. Renal medullary HIF-1α levels were induced by either transfection of HIF-1α expression plasmid or chronic infusion of CoCl₂ into the renal medulla, which was accompanied by increased expressions of anti-hypertensive genes, cyclooxygenase-2 and heme oxygenase-1. Overexpression of HIF-1α transgenes in the renal medulla enhanced the pressure natriuresis, promoted the sodium excretion and reduced sodium retention after salt overload. As a result, hypertension induced by 2-week high salt was significantly attenuated in rats treated with HIF-1α plasmid or CoCl₂. These results suggest that an abnormal HIF-1α in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1α levels in the renal medulla could be a therapeutic approach for the trea...Continue Reading

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Citations

Aug 10, 2012·Experimental & Molecular Medicine·Zhengchao WangYong Cheng
Feb 20, 2016·Current Hypertension Reports·Farhanah Yousaf, Bruce Spinowitz
Aug 27, 2013·Journal of Receptor and Signal Transduction Research·Song Mao, Songming Huang
Jan 27, 2015·Nitric Oxide : Biology and Chemistry·Pan HuangHongfang Jin
Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anita MaticInes Drenjancevic
Aug 23, 2018·American Journal of Physiology. Renal Physiology·Zhengchao WangNingjun Li
Aug 1, 2019·American Journal of Physiology. Renal Physiology·Robert L RepettiRajeev Rohatgi
Aug 9, 2020·Biochemical Genetics·Olga GawrysElzbieta Kompanowska-Jezierska
Mar 14, 2014·American Journal of Physiology. Renal Physiology·Zhengchao WangNingjun Li

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