Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

Molecular and Cellular Biochemistry
Ruixue HuangFei Yang

Abstract

High mobility group A1 (HMGA1), as a major member of HMGA family, plays an important part in promotion of cell proliferation and motility, induction of epithelial-mesenchymal transition, and maintenance of stemness, but little is known about the pathological role of HMGA1 in breast cancer patients. The aim of this study was to identify the pathological roles of HMGA1 in breast cancer. In our results, we found that mRNA and protein expression levels of HMGA1 were markedly higher in breast cancer tissues than in normal breast tissues. Using immunohistochemistry, high levels of HMGA1 protein were positively correlated with the status of histological grade (I-II vs. III-IV; P = 0.023), clinical stage (I-II vs. III-IV; P = 0.008), tumor size (T1-T2 vs. T3-T4; P = 0.015), lymph node metastasis (N0-N1 vs. N2-N3; P = 0.002), distant metastasis (M0 vs. M1; P < 0.001), and triple-negative breast cancer (No vs. Yes; P = 0.014) of breast cancer patients. Patients with higher HMGA1 expression had a significantly shorter overall survival time than did patients with low HMGA1 expression. Multivariate analysis indicated that the level of HMGA1 expression was an independent prognostic indicator (P < 0.001) for the survival of patients with brea...Continue Reading

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Citations

Jul 26, 2019·Journal of Experimental & Clinical Cancer Research : CR·Kai TengDan Xie
Jul 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Rossella ZaninGuidalberto Manfioletti
Nov 2, 2017·Journal of Cellular Biochemistry·Zahra BaziHossein Ghanbarian
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Mar 24, 2016·Journal of Translational Medicine·Jing ZhongRen-xian Cao
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Nov 30, 2019·International Journal of Molecular Sciences·Olga MéndezJosep Villanueva
Jan 8, 2019·Journal of Cellular and Molecular Medicine·Yuhong WangLingchuan Guo
Jul 14, 2019·Molecular Cancer Research : MCR·Claire TolzaIsabelle Jariel-Encontre
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Behzad MansooriBehzad Baradaran

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