Overexpression of human HSP27 protects sensory neurons from diabetes.

Neurobiology of Disease
L KorngutDouglas W Zochodne

Abstract

To evaluate whether augmenting neuronal protective mechanisms might slow or arrest experimental diabetic peripheral neuropathy (DPN). DPN is one of the most common neurodegenerative disorders and is rising in prevalence. How it targets sensory neurons is uncertain; the disorder is irreversible and untreatable. We explored the intrinsic protective properties of overexpressed human HSP27 on experimental DPN. HSP27 is a small pro-survival heat shock protein that also increases axonal regeneration. Experimental diabetes was superimposed on mice overexpressing a human HSP27 transgene and its impact was evaluated on epidermal innervation, behavioral tests of sensation and electrophysiological indices of DPN. Mice that overexpress human HSP27 in their sensory and motor neurons and that were made diabetic for 6 months by streptozotocin treatment were protected from a range of neuropathic abnormalities, including loss of footpad thermal sensation, mechanical allodynia, loss of epidermal innervation, and slowing of sensory conduction velocity. The protection was selective for sensory neurons in comparison to motor neurons and at 6 months provided better protection in female than male mice. Markers of RAGE-NFκB activation were attenuated ...Continue Reading

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Citations

Jun 4, 2013·Trends in Neurosciences·Jennifer ZenkerRoman Chrast
Mar 13, 2014·ILAR Journal·Phillipe D O'BrienEva L Feldman
Dec 3, 2014·Neuroscience Letters·Douglas W Zochodne
Mar 10, 2015·Journal of Diabetes and Its Complications·Kanhaiya SinghKiran Singh
Mar 19, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Ngan Pan Bennett AuChi Him Eddie Ma
Jun 20, 2016·Current Diabetes Reports·Rick T Dobrowsky
Feb 23, 2017·American Journal of Physiology. Endocrinology and Metabolism·Cristiane L de la HozDouglas W Zochodne
Mar 3, 2017·Disease Models & Mechanisms·Masaki KobayashiDouglas W Zochodne
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Jul 16, 2019·Current Opinion in Neurology·Douglas W Zochodne
Jun 24, 2020·Journal of the Peripheral Nervous System : JPNS·Masaki Kobayashi, Douglas W Zochodne
Dec 15, 2017·International Journal of Molecular Sciences·Stefania BelliniGabriella Gruden
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Sep 3, 2019·Neuroscience Letters·Miles S Lyon, Carol Milligan
Apr 25, 2021·Journal of Neuroimmunology·Kathleen M Hagen, Shalina S Ousman

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