Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinomas

American Journal of Obstetrics and Gynecology
A D SantinS Pecorelli

Abstract

Kallikrein 10 is a secreted serine protease recently implicated in the growth and invasion of several human tumors. The goal of this study was to investigate the expression and secretion levels in vitro and in vivo of kallikrein 10 in uterine serous papillary carcinoma, a highly aggressive variant of endometrial tumor. Human kallikrein 10 gene expression levels were evaluated in 11 snap-frozen uterine serous papillary carcinoma biopsies and 6 normal endometrial cell biopsies by real-time polymerase chain reaction. Secretion of kallikrein 10 protein by 10 primary tumor cultures including 3 uterine serous papillary carcinomas, 2 endometrioid carcinomas, and 5 ovarian serous papillary tumors was measured using a sensitive ELISA. Finally, kallikrein 10 concentration in 75 serum and plasma samples from 22 healthy women, 20 women with benign diseases, 21 women with endometrioid carcinomas, and 12 uterine serous papillary carcinoma patients was studied. Kallikrein 10 gene expression levels were significantly higher in uterine serous papillary carcinoma when compared with normal endometrial cell biopsies (mean copy number by real time polymerase chain reaction = 743 versus 1.4; uterine serous papillary carcinoma versus endometrioid car...Continue Reading

References

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Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Jun 28, 2000·American Journal of Obstetrics and Gynecology·D J Dotters
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Jul 13, 2002·Expert Review of Anticancer Therapy·Martin J CannonAlessandro D Santin
Jun 25, 2003·Gynecologic Oncology·Hyun S ShvartsmanRosemarie Schmandt
Nov 2, 2004·Nature Reviews. Cancer·Carla A Borgoño, Eleftherios P Diamandis
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandro D SantinSergio Pecorelli
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kristina L BondurantMartin J Cannon

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Citations

May 23, 2012·Journal of Medicinal Chemistry·Giuseppe CaliendoLuiz Juliano
Dec 18, 2013·Women's Health·Jonathan D BlackAlessandro D Santin
Jun 15, 2013·Thrombosis and Haemostasis·J DornM Schmitt
Feb 5, 2014·Critical Reviews in Clinical Laboratory Sciences·Julia DornViktor Magdolen
Jun 19, 2009·British Journal of Cancer·E CoccoA D Santin
Dec 14, 2011·Expert Review of Anticancer Therapy·Karim S El-SahwiAlessandro D Santin

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