Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma

IUBMB Life
Yonglong ZhongZongrong Li

Abstract

Kinesin family member 18A (KIF18A), as a member of the kinesin superfamily, is significantly overexpressed and abnormally functions in various human cancers. But, its expression profiling in the lung adenocarcinoma (LUAD) remains unclear. In the present work, using the data derived from the Cancer Genome Atlas (TCGA), we assessed the expression pattern and prognostic value of KIF18A in LUAD. In addition, we analyzed the underlying mechanism of its gene dysregulation. Experimental and bioinformatic analysis results showed that KIF18A expression was dramatically increased in LUAD tissues compared with the normal counterparts. Moreover, the patients with high KIF18A expression had significantly poorer overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate analyses indicated that increased KIF18A expression was independently associated with unfavorable OS and RFS. In addition, by analyzing deep sequencing data from TCGA-LUAD, we found that KIF18A mutation was detected in 2.6% of LUAD cases, and increased KIF18A expression was associated with genetic amplification rather than DNA methylation. Moreover, gene co-expression network analysis revealed that a total of 339 KIF18A co-expressed genes were detec...Continue Reading

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Citations

Aug 21, 2020·Technology in Cancer Research & Treatment·Xiao-Hui WangXiao-Peng Xu
Apr 20, 2021·Biochemical and Biophysical Research Communications·Lu-Xi QianLi Yin
Jul 24, 2021·Journal of Biomedical Informatics·A KosvyraI Chouvarda
Aug 10, 2021·Computational and Mathematical Methods in Medicine·Aifeng ChenXuai Lin

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