Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Tatsuya KatoKazuhiro Yasufuku

Abstract

High-level expression of kinesin family member 23 (KIF23), a member of microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division, has been observed in a variety of human malignancies. The aims of the present study were to observe the expression of KIF23 in lung cancer, examine the role of KIF23 in lung cancer cell growth and/or survival by small interfering RNA experiments, and explore its clinicopathologic significance and evaluate KIF23 expression as a prognostic marker. Quantitative reverse transcription-polymerase chain reaction analysis was performed to detect the expression of KIF23 mRNA using metastatic lymph nodes from patients with advanced lung cancer obtained by endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and primary lung tumors through surgical sample. The role of KIF23 in cancer cell growth was examined by small interfering RNA experiments. A total of 339 lung cancers were analyzed immunohistochemically on tissue microarrays to examine the expression of KIF23 protein and its clinicopathologic significance. KIF23 transcript was found to be overexpressed in the great majority of metastatic lymph nodes from advanced lun...Continue Reading

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Citations

Jun 9, 2017·British Journal of Cancer·Jie WangJianxin Jiang
Apr 18, 2019·Cancers·Gerhard JungwirthChristel Herold-Mende
Aug 29, 2019·Functional & Integrative Genomics·Tingting ChenXing Xie
Jan 22, 2019·Molecular Medicine Reports·Zhang-Yi LiChang-Chun Li
Jun 10, 2016·International Journal of Oncology·Tatsuya KatoKazuhiro Yasufuku
Nov 15, 2016·International Journal of Oncology·Tatsuya KatoKazuhiro Yasufuku
Nov 3, 2020·World Journal of Gastrointestinal Oncology·Wei-Tian LiangKai Li
May 22, 2021·Frontiers in Genetics·Zheng ZhaoLi-Hua Sun

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