Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits

Diabetologia
Shuji KitajimaJianglin Fan

Abstract

Dysfunctions of lipoprotein lipase (LPL) have been found to be associated with dyslipidaemias, atherosclerosis, obesity and insulin resistance. There are two conflicting hypotheses regarding the roles of LPL in glucose metabolism and insulin resistance. Whether systemically increased LPL activity would be beneficial or detrimental to insulin sensitivity is yet to be resolved. To address this issue, we studied transgenic rabbits overexpressing human LPL transgene. LPL transgenic and control rabbits were fed a 10% high-fat diet (HFD) for 16 weeks. To evaluate glucose metabolism, we compared plasma levels of glucose and insulin in transgenic rabbits with control rabbits and performed an intravenous glucose tolerance test. In addition, we measured adipose tissue accumulation in HFD-fed rabbits. Increased LPL activity in transgenic rabbits resulted in a significant reduction of plasma triglycerides and non-esterified fatty acids, but not in basal levels of glucose and insulin. HFD feeding induced an elevation of plasma glucose levels accompanied by hyperinsulinaemia in control rabbits, but was significantly inhibited in transgenic rabbits. The intravenous glucose tolerance test showed that transgenic rabbits had faster glucose clear...Continue Reading

References

Oct 1, 1992·Journal of Nutritional Science and Vitaminology·H DannoS Kimura
Aug 1, 1991·The American Journal of Physiology·T C FureszC H Smith
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J K KimG I Shulman
Feb 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ouliana ZiouzenkovaJorge Plutzky
May 15, 2003·International Journal of Experimental Diabesity Research·Weidong YinYongzong Yang
Sep 3, 2003·Pharmacology & Therapeutics·Jianglin Fan, Teruo Watanabe
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Weidong YinKechao Tang
Feb 10, 2004·Metabolism: Clinical and Experimental·Masataka KusunokiYutaka Nakaya

❮ Previous
Next ❯

Citations

Jan 11, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dolores CorellaJose M Ordovas
Jul 3, 2013·Journal of Translational Medicine·Yvelise FerroTiziana Montalcini
May 9, 2006·The Journal of Reproduction and Development·Naomi KashiwazakiTomo Inomata
Jan 11, 2008·Journal of Animal Physiology and Animal Nutrition·S ZhaoE Liu
Apr 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S W Rabkin
Nov 25, 2004·Metabolism: Clinical and Experimental·Enqi LiuJianglin Fan
Jul 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Osamu HanyuYoshifusa Aizawa
Oct 4, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shuji KitajimaJianglin Fan
Oct 16, 2014·European Journal of Nutrition·Zhenya IvanovaIvan Penchev Georgiev
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Feb 3, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ding AnBrian Rodrigues
Apr 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Dake QiBrian Rodrigues
Feb 18, 2021·Metabolomics : Official Journal of the Metabolomic Society·Yuichiro NishidaKeitaro Tanaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.