Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jun WangZengjun Wang

Abstract

Tumor recurrence and metastasis remain the major obstacles for the successful treatment of patients diagnosed with prostate cancer (PCa). In recent years, long non-coding RNAs (lncRNAs) have been considered as key regulators of tumor behavior. In this study, we investigated the biological role and clinical relevance of the lncRNA LOC400891 in prostate cancer. Using of lncRNAs expression chips screening and the biological analysis, we found the target lncRNA (LOC400891). Moreover, the expression levels of lncRNA LOC400891 in PCa tissues and cell lines were evaluated by quantitative real-time PCR (qRT-PCR), and its association with biochemical recurrence-free survival of patients was analyzed by statistical analysis. Furthermore, the effect of LOC400891 on proliferation, migration, and invasion was studied in PCa cells. We found that the expression level of LOC400891 was higher in PCa tissues and cells compared to adjacent non-tumor tissues and normal prostate stromal immortalized cells WPMY-1. The patients with higher LOC400891 expression had an advanced clinical features and a shorter biochemical recurrence-free survival time than those with lower LOC400891 expression. Furthermore, multivariate analysis showed that the status o...Continue Reading

References

Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·V SrikantanS Srivastava
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Savagner
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Feb 23, 2005·Prostate Cancer and Prostatic Diseases·L LiT C Thompson
Apr 2, 2005·Annales pharmaceutiques françaises·N Pommery, J-P Hénichart
Dec 27, 2005·Mini Reviews in Medicinal Chemistry·Nicole Pommery, Jean-Pierre Hénichart
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark A WatsonRebecca L Aft
Aug 24, 2010·Human Molecular Genetics·Maite Huarte, John L Rinn
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Jun 24, 2011·Journal of Cancer Research and Clinical Oncology·M Moshahid Alam RizviA K Mandal
Aug 5, 2011·Science Translational Medicine·Scott A TomlinsArul M Chinnaiyan
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Jan 20, 2012·Cancer Research·Takeshi NiinumaYasuhisa Shinomura
Mar 7, 2012·Journal of Molecular Endocrinology·Yunli ZhouAnne Klibanski
Mar 20, 2012·European Urology·Melissa M CenterFreddie Bray
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 4, 2013·Nature Structural & Molecular Biology·Zhou DuX Shirley Liu

❮ Previous
Next ❯

Citations

Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yalong ZhangYao Li
Mar 9, 2017·International Journal of Environmental Research and Public Health·Junli DengYuan-Shan Zhu
Oct 19, 2017·Experimental and Therapeutic Medicine·Bailiang YeYixiong Shi
Oct 23, 2019·International Journal of Oncology·Xiaozeng LinDamu Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.