Overexpression of long noncoding RNA H19 indicates a poor prognosis for cholangiocarcinoma and promotes cell migration and invasion by affecting epithelial-mesenchymal transition

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yi XuYunfu Cui

Abstract

Cholangiocarcinoma (CCA) is a deadly disease that poorly responds to chemotherapy and radiotherapy and whose incidence has increased worldwide. Furthermore, long noncoding RNAs (lncRNAs) play important roles in multiple biological processes, including tumorigenesis. Specifically, H19, the first discovered lncRNA, has been reported to be overexpressed in diverse human carcinomas, but the overall biological role and clinical significance of H19 in CCA remains unknown. In the present study, expression levels of H19 were investigated in CCA tissues and cell lines and were correlated with clinicopathological features. Moreover, we explored the functional roles of H19 depletion in QBC939 and RBE cells, including cell proliferation, apoptosis, migration, invasion and epithelial-to-mesenchymal transition (EMT). The results indicated that H19 was upregulated in CCA tissue samples and cell lines, and this upregulation was associated with tumor size, TNM stage, postoperative recurrence and overall survival in 56 patients with CCA. Moreover, knockdown of H19 followed by RNA silencing restrained cell proliferation and promoted apoptosis. In addition, H19 suppression impaired migration and invasion potential by reversing EMT. Overall, our fi...Continue Reading

References

May 12, 2007·Mayo Clinic Proceedings·Steven R AlbertsJames A Martenson
Jun 7, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Boris Blechacz, Gregory J Gores
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Aug 17, 2012·Gut·Shahid A KhanUNKNOWN British Society of Gastroenterology
Mar 4, 2014·Lancet·Nataliya Razumilava, Gregory J Gores
Mar 12, 2016·Cancer Letters·Ailin ZhangHong Yang
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Congxiu HuangYu Lin
Sep 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiguo LiDefeng Kuang
Oct 8, 2016·Journal of Experimental & Clinical Cancer Research : CR·Shou-Hua WangZhi-Wei Quan
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fei MaJun Ding

❮ Previous
Next ❯

Citations

Sep 6, 2017·International Journal of Molecular Sciences·Hsiang-Cheng ChiKwang-Huei Lin
Mar 20, 2019·Journal of Cellular Physiology·Jinglin LiYunfu Cui
Apr 21, 2018·Expert Review of Anticancer Therapy·Charupong SaengboonmeeSopit Wongkham
Jul 25, 2019·Cellular and Molecular Life Sciences : CMLS·Clément LecerfEric Adriaenssens
Apr 26, 2020·Journal of Clinical Medicine·Dino BekricChristian Mayr
Sep 13, 2020·Journal of Cancer Research and Clinical Oncology·Olga Y BureninaOlga A Dontsova
Oct 24, 2019·Experimental and Therapeutic Medicine·Fangting XuWei Gao
Oct 2, 2020·Biomolecules·Yu-Chan ChangMichael Hsiao
Apr 23, 2020·International Journal of Oncology·Yinghao LvYongfu Zhao
Dec 4, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xue-Ting HuXiang Xu
Jan 7, 2021·Molecular Medicine·Jingting WangBangwei Cao
Nov 12, 2020·Cancer Management and Research·Wei Yuan HaoJia Ping Zheng
Sep 1, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aude MerdrignacCédric Coulouarn
Aug 2, 2021·Archives of Oral Biology·Eun Young LeeHae Ryoun Park
Jan 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi XuYunfu Cui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.