Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer

International Journal of Oncology
Hideki UjiieKazuhiro Yasufuku

Abstract

Melanoma-associated antigens (MAGE) are expressed in different type of cancers including lung cancer and have been shown to be functionally related to p53 tumor suppressor gene. Little is known about the relationship between MAGE genes and p53 aberrant expression in lung cancer. The aims of this study were to observe the expression of MAGEA2, examine the role of MAGEA2 in lung cancer survival, investigate its correlation between MAGEA2 and p53, and explore its clinicopathologic significance as a prognostic marker. Quantitative reverse transcription-polymerase chain reaction was performed to detect the expression of MAGEA2 using 36 primary tumors and 31 metastatic lymph nodes from patients with lung cancer. The role of MAGEA2 in cancer cell growth and in the regulation of p53 downstream genes were examined using small interfering RNA. The expression of MAGEA2 and p53 were analyzed immunohistochemically using tissue microarray from 353 resected lung specimens. High-level expression of MAGEA2 (High-MAGEA2) was confirmed in lung tumors with high frequency. Inhibiting MAGEA2 expression effectively suppressed cancer cell growth and decreased the expression of p53 downstream target genes in vitro. In adenocarcinoma, High-MAGEA2 was st...Continue Reading

References

Jul 1, 1994·International Journal of Cancer. Journal International Du Cancer·S GazzeriC Brambilla
Mar 15, 1994·International Journal of Cancer. Journal International Du Cancer·P WeynantsT Boon
Dec 31, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sanghoon JheonHee-Kyung Chang
Jan 24, 2004·The Journal of Biological Chemistry·Toshiharu SakuraiJun Fujita
Apr 20, 2005·Oncogene·Sandra L Harris, Arnold J Levine
Jul 22, 2005·Nature Reviews. Cancer·Andrew J G SimpsonLloyd J Old
May 3, 2006·Cancer Research·Tobias PeikertSuzy A A Comhair
Jul 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Martin MonteClaudio Schneider
May 20, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ryo NagashioTakashi Nakajima
Oct 25, 2008·Nature·Li DingRichard K Wilson
Nov 7, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ryo NagashioIsao Okayasu
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jun 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Seol Bong YooSook Whan Sung
Mar 8, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya KatoMitsuhito Kaji
Jun 22, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya KatoMitsuhito Kaji
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Nov 26, 2011·Cell Death and Differentiation·L Y PecheC Schneider
Apr 11, 2012·Journal of Surgical Oncology·Tatsuya KatoMitsuhito Kaji
Oct 1, 2011·Journal of Bronchology & Interventional Pulmonology·Takahiro NakajimaKazuhiro Yasufuku
Jul 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hyo Sup ShimA John Iafrate
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hideki UjiiePrasad S Adusumilli
Aug 27, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jean-Louis PujolFrédéric F Lehmann
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 19, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatsuya KatoKazuhiro Yasufuku
May 31, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yoon Jin ChaHyo Sup Shim
Aug 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingo MecklenburgPeter Kufer

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Citations

Nov 28, 2021·Journal of Cancer Research and Clinical Oncology·Leili Saeednejad ZanjaniMonireh Mohsenzadegan

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