Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Li-Ying ZhanQiang-Min Huang

Abstract

MicroRNA are significant regulators of neuropathic pain development. Neuroinflammation contributes a lot to the progression of neuropathic pain. miR-381 is involved in various pathological processes. However, the role of miR-381 in neuropathic pain development remains barely understood. Therefore, in our study, we aimed to investigate the effects of miR-381 on the process of neuropathic pain progression by establishing a rat model using chronic sciatic nerve injury (CCI). Here, we observed that miR-381 was dramatically decreased in CCI rats. Up-regulation of miR-381 strongly reduced neuropathic pain behaviors including mechanical and thermal hyperalgesia. In addition, inflammatory cytokine expression, including IL-6, IL-10 and TNF-α were significantly repressed by overexpression of miR-381. High mobility group box 1 protein (HMGB1) and Chemokine CXC receptor 4 (CXCR4) participate in neuropathic pain development. In our present study, HMGB1 and CXCR4 were predicted as direct targets of miR-381 by employing bioinformatics analysis. Overexpression of miR-381 was able to restrain the expression of HMGB1 and CXCR4 greatly. The direct correlation between HMGB1 and CXCR4 and miR-381 was confirmed in our research. Furthermore, we found...Continue Reading

References

Jul 10, 1999·Science·H WangK J Tracey
Sep 17, 2004·Nature·Victor Ambros
Oct 21, 2010·Annals of the New York Academy of Sciences·Michela VezzoliPatrizia Rovere-Querini
Aug 9, 2012·Journal of Pain and Symptom Management·Erica Brandão de Moraes VieiraRicardo Clayton Silva Jansen
Feb 7, 2014·BMJ : British Medical Journal·Steven P Cohen, Jianren Mao
Oct 9, 2014·Advances in Biological Regulation·Mario AcunzoCarlo M Croce
Oct 10, 2015·Bioscience Reports·Jia MingJun Jiang
Jan 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bairong XiaGe Lou
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaojuan XieDongmei Fan
May 23, 2017·Frontiers in Molecular Neuroscience·Songxue SuWeidong Zang
Jun 6, 2017·Pharmacology & Therapeutics·María José López-GonzálezAlexandre Favereaux
Feb 2, 2018·Journal of Neuroinflammation·Zhiqiang PanChi Wai Cheung

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Citations

May 10, 2020·Anesthesia and Analgesia·Juan P CataHolger K Eltzschig
Jun 20, 2020·Journal of Molecular Neuroscience : MN·Yuetao MaMingcang Wang
Oct 12, 2019·Journal of Cellular Physiology·Lili Huang, Li Wang
Sep 18, 2020·European Journal of Medical Research·Piqiang ZhangHongjuan Li
Mar 29, 2020·Molecular Biology Reports·Francesca PolitoM'Hammed Aguennouz
Nov 3, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Hongyan XuGuangjun Xia
May 26, 2020·Pharmacology & Therapeutics·Bao-Chun JiangYong-Jing Gao
Aug 19, 2021·Neurochemical Research·Pengfei GaoXianlong Zhang
Nov 9, 2021·Experimental Brain Research·Junfeng LiaoXiaoyu Lv

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