Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients

Prostate Cancer and Prostatic Diseases
T KamigaitoJ Nakayama

Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) is a glycan essential for fundamental cellular processes such as transcription/translation, nuclear transport, protein stability and protein-protein interactions. However, the role of O-GlcNAc in prostate cancer progression of patients remains poorly unknown. Here we investigated the clinicopathological significance of O-GlcNAc expression level in prostate cancer. O-GlcNAc expression level in prostate cancer cells was determined by immunohistochemistry of prostate biopsy specimens obtained from 56 patients later treated with hormone deprivation therapy comparing with adjacent normal prostate glands in the same sections. Overall survival was determined by the Kaplan-Meier and Cox proportional hazards methods with univariate and multivariate models. The effects of reduced O-GlcNAc expression level on proliferation and invasion of prostate cancer LNCaP cells were examined using small interfering RNA (siRNA) targeting O-GlcNAc transferase (OGT), the enzyme responsible for O-GlcNAc biosynthesis. Defining cancer cells showing stronger cytoplasmic staining than normal prostate glands as overexpression of O-GlcNAc, 39% of prostate cancer patients were categorized as overexpression. The Kaplan-M...Continue Reading

References

Aug 1, 1996·Diabetes·D A McClain, E D Crook
May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Oi HaradaJun Nakayama
Apr 5, 2008·Current Opinion in Genetics & Development·Ralph J DeberardinisCraig B Thompson
Oct 23, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ralph J DeBerardinis
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
May 15, 2010·Trends in Biochemical Sciences·C SlawsonG W Hart
Jul 9, 2010·Cancer Research·Yuchao GuWengong Yu
Jan 25, 2011·Biochimica Et Biophysica Acta·Wenyi MiWengong Yu
Aug 19, 2011·Nature Reviews. Cancer·Chad Slawson, Gerald W Hart
Jan 26, 2012·The Journal of Biological Chemistry·Thomas P LynchMauricio J Reginato

❮ Previous
Next ❯

Citations

Oct 16, 2014·Clinical and Experimental Medicine·Katarzyna StarskaAnna Krześlak
May 6, 2016·Frontiers in Oncology·Kekoa TaparraNatasha E Zachara
Apr 20, 2016·Nature Reviews. Urology·Jennifer MunkleyDavid J Elliott
Jun 12, 2014·Frontiers in Oncology·Rafaela Muniz de QueirozWagner Barbosa Dias
Nov 27, 2014·Frontiers in Endocrinology·Parunya ChaiyawatVoraratt Champattanachai
May 2, 2016·Pathology, Research and Practice·Tae Jung Jang, Ui Jung Kim
Jun 28, 2016·Journal of Molecular Biology·Christina M FerrerMauricio J Reginato
Jun 19, 2014·Glycobiology·Daniel CompagnoDiego J Laderach
Feb 6, 2017·Endocrine-related Cancer·Jennifer Munkley
Mar 22, 2019·International Journal of Molecular Sciences·Emma Scott, Jennifer Munkley
Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kenneth Kin Lam WongEsther M Verheyen
May 14, 2019·Oncotarget·Nicole Morin Jaskiewicz, David H Townson
Oct 23, 2014·The Journal of Biological Chemistry·Zhiyuan Ma, Keith Vosseller
Jan 13, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tassaporn KongkaewSuttichai Krisanaprakornkit
Oct 12, 2018·Endocrine-related Cancer·S PrekovicF Claessens
Mar 21, 2019·Frontiers in Oncology·Rafaela Muniz de QueirozWagner Barbosa Dias
Dec 19, 2019·International Journal of Molecular Sciences·Jarrod W BarnesRaed A Dweik
May 11, 2017·Protein & Cell·Donglu WuJingji Jin
Jul 3, 2020·Molecular Cancer Research : MCR·Harri M ItkonenSuzanne Walker
Nov 7, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Divya ThomasPrakash Radhakrishnan
Jan 9, 2021·Chemical Reviews·Junfeng MaGerald W Hart
Nov 17, 2020·Frontiers in Oncology·Donglu WuHaoming Luo
Jan 26, 2021·OncoTargets and Therapy·Yifan ChenXudong Yao
Feb 5, 2021·Cancers·Hiroki Sekine, Hozumi Motohashi
Mar 22, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Vivek MakwanaShailendra Anoopkumar-Dukie
Nov 26, 2021·Asia-Pacific Journal of Clinical Oncology·Na HeMin Liu
Sep 2, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Thamonwan SombutthaweesriChayarop Supanchart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.