Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation

Oncology Reports
Yuwen LiChuanlong Zhu

Abstract

Opa interacting protein 5 (OIP5) overexpression is associated with human carcinoma. However, its biological function, underlying mechanism and clinical significance in liver cancer remain unknown. In the present study, the effects of OIP5 expression on liver cancer, and the mechanisms regulating these effects, were investigated. OIP5 expression was measured in human hepatocellular carcinoma (HCC) tissues and liver cancer cell lines. The effect of OIP5 knockdown on tumorigenesis was also detected in nude mice, and differentially‑expressed genes (DEGs) were identified and their biological functions were identified. The results indicated that OIP5 expression was significantly upregulated in HCC tissues and four liver cancer cell lines (P<0.01). Increased OIP5 protein expression significantly predicted reduced survival rate of patients with HCC (P<0.01). OIP5 knockdown resulted in the suppression of proliferation and colony forming abilities, cell cycle arrest at the G0/G1 or G2/M phases, and promotion of cell apoptosis. A total of 628 DEGs, including 87 upregulated and 541 downregulated genes, were identified following OIP5 knockdown. Functional enrichment analysis indicated that DEGs were involved in 'RNA Post‑Transcriptional Mod...Continue Reading

Citations

Jun 4, 2021·Frontiers in Oncology·Jiaxin LiangQianjin Liao

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Datasets Mentioned

BETA
GSE36411
GEPIA

Methods Mentioned

BETA
surgical resection
nuclear translocation
transfection
transfect
Protein Assay
GTPase
flow cytometry
gene knockdown
xenografts
two-hybrid

Software Mentioned

GEPIA
IPA
GeneChipPrimeview
SPSS
Image Pro - Plus
WinMDI
GeneSpring

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