Abstract
Adenomatous hyperplasia in the human liver with cirrhosis is similar to the hyperplastic nodule in rat hepato-carcinogenesis in that the mdr gene or its product P-glycoprotein is overexpressed. We immunohistochemically stained archival formalin-fixed, paraffin-embedded sections of 15 adenomatous hyperplasias with or without hepatocellular carcinoma in livers with cirrhosis, using the avidin-biotin-complex method and the JSB-1 monoclonal antibody which specifically binds the cytoplasmic epitope of P-glycoprotein. Of 15 cases with adenomatous hyperplasia, four were found solely in livers with cirrhosis. In six cases, adenomatous hyperplasia and hepatocellular carcinoma were found in the same liver separately. Hepatocellular carcinoma was discovered within adenomatous hyperplasia in five cases. All 15 livers with cirrhosis and those with adenomatous hyperplasia were positively stained for P-glycoprotein. When the grade of staining was compared between adenomatous hyperplasia and the surrounding liver, P-glycoprotein was overexpressed in 12 of 15 cases with adenomatous hyperplasia. P-glycoprotein was also stained more strongly in well-differentiated hepatocellular carcinoma than in the liver, but the staining grade of hepatocellula...Continue Reading
References
May 1, 1978·Journal of Clinical Pathology·P P AnthonyL H Sobin
Feb 19, 1992·Journal of the National Cancer Institute·C C HuangJ R Gu
Jan 1, 1992·Molecular Carcinogenesis·H NakatsukasaS S Thorgeirsson
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E GeorgesV Ling
Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Cordon-CardoM R Melamed
Nov 7, 1990·Journal of the National Cancer Institute·T MizoguchiS Akiyama
Nov 10, 1990·Lancet·T TakayamaH Hasegawa
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·R J ScheperJ Lankelma
Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
May 3, 1989·Journal of the National Cancer Institute·S E SalmonW S Dalton
Jun 7, 1989·Journal of the National Cancer Institute·H KanamaruM M Gottesman
Nov 2, 1988·Journal of the National Cancer Institute·R K Burt, S S Thorgeirsson
Nov 1, 1988·The British Journal of Surgery·N NagasueT Nakamura
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C R FairchildK H Cowan
May 29, 1987·Science·S S ThorgeirssonM M Gottesman
Dec 1, 1984·Cancer·N NagasueI Yuuki
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
May 1, 1954·Cancer·H A EDMONDSON, P E STEINER
Citations
Aug 18, 2009·Cancer Chemotherapy and Pharmacology·Karnati R RoyPallu Reddanna
Jun 25, 2013·Biochemical Pharmacology·Sheng-Fan WangYune-Fang Ueng
Mar 9, 2000·Journal of Hepatology·K N KhanM Yano
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christina ZiemannKaren I Hirsch-Ernst
Nov 7, 1999·Clinical Nuclear Medicine·Y S KimC H Park
Aug 1, 1997·Journal of Gastroenterology and Hepatology·Y Y ChouH C Hsu
Apr 16, 2015·Expert Opinion on Drug Metabolism & Toxicology·Darren Michael MossMarco Siccardi
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Ching-Ping TsengKelvin Chingchung Tseng
Jan 20, 2005·The Medical Clinics of North America·Paul H Hayashi, Adrian M Di Bisceglie
Sep 9, 2010·Pharmaceutics·Tomoya SakuradaShiro Ueda
Oct 31, 2006·World Journal of Gastroenterology : WJG·Yoshiyuki TakaharaNorifumi Kawada
Feb 9, 2017·Archives of Toxicology·Thomas Efferth, Manfred Volm
Jun 11, 2005·World Journal of Gastroenterology : WJG·Yu HanHong Zhu
Apr 28, 2004·World Journal of Gastroenterology : WJG·Hai WangFa-Zu Qiu
Mar 11, 2006·Infectious Disease Clinics of North America·Paul H Hayashi, Adrian M Di Bisceglie