PMID: 7545256Sep 1, 1995Paper

Overexpression of P-glycoprotein in untreated AFP-producing gastric carcinoma

Journal of Surgical Oncology
D K DharT Nakamura

Abstract

P-glycoprotein (P-gly), which is responsible for the phenotypic expression of multidrug resistance in cancerous tissue was stained immunohistochemically in previously untreated alpha-fetoprotein (AFP)-producing (n = 20) and nonproducing gastric cancers (n = 20). P-gly, AFP, and carcinoembryonic antigen(CEA) were stained in formalin-fixed paraffin-embedded tissue sections immunohistochemically using the monoclonal antibody JSB-1, anti-AFP, and anti-CEA, respectively. DNA ploidy pattern was determined by Fluorescence Activated Cell Sorter (FACS) analyzer. P-gly was significantly overexpressed in AFP producing gastric cancers (60%) than in AFP nonproducing ones (20%) (P < 0.01). When the result of P-gly staining was analyzed among the AFP-positive cases, P-gly positivity did not emerge either as a significant prognostic factor or as a predictor of the metastatic potentiality of the tumor. The intrinsic overexpression of P-gly in AFP producing gastric cancers proves its biological and morphological similarities to hepatocellular carcinoma. The significantly (P < 0.05) higher incidence of P-gly in diploid tumors indicate that expression of this phenotype might be related to the differentiation of the tumor. P-gly was overexpressed i...Continue Reading

References

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Citations

Aug 10, 2012·World Journal of Gastroenterology : WJG·Shi ChenChao-Nan Qian
Dec 1, 2006·Expert Opinion on Drug Discovery·Divya Khaitan, B S Dwarakanath
Dec 3, 2014·Cancer Letters·Wenhui SunWeihua Gong
Dec 4, 2004·Internal Medicine·Kimihiko YanaokaMasao Ichinose

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