Overexpression of p53 protein during pancreatitis

British Journal of Cancer
H MaackeH Kalthoff

Abstract

Overexpression of p53 correlates with neoplasia in many cytological specimens. To test the specificity of overexpressed p53 as a tumour marker for the detection of pancreatic cancer, we analysed cytological specimens of pancreatic juice samples from patients with pancreatitis or pancreatic carcinoma (n = 42) for p53 protein overexpression. p53 protein overexpression was found in 59% of patients with pancreatitis and 67% of patients with pancreatic carcinoma. Thus, the assessment of p53 protein overexpression is not useful in the diagnosis of pancreatic cancer. Overexpressed p53 during pancreatitis appears to be wild-type p53. Overexpression of p53 may result from DNA damage occurring during chronic inflammation. It is well established that p53 can induce apoptosis upon DNA damage. Consequently, we found apoptotic cell death in five out of five tested cytological preparations from patients with pancreatitis as well as in one out of one pancreatic carcinoma specimen.

Citations

Jul 5, 2008·Journal of Gastroenterology·Lipi SinghJai Dev Wig
Apr 22, 2003·Pathology Oncology Research : POR·Gábor ElekAkos Pap
Mar 17, 2010·Diagnostic Cytopathology·Viktor ShtilbansDavid E Burstein
Sep 17, 2011·Clinical & Developmental Immunology·Shigeo KoidoHisao Tajiri
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Amedeo AmedeiDomenico Prisco
Jul 11, 2001·Experimental Biology and Medicine·G GomezG H Greeley
Apr 17, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Binoy ChandyCherie-Ann Nathan
Mar 20, 2013·BioMed Research International·Elena NiccolaiAmedeo Amedei
May 18, 2016·World Journal of Gastroenterology : WJG·Mikio KajiharaShigeo Koido

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Sovetskaia meditsina
Iu A NesterenkoIu V Dzhalalov
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
T HiraneA Yachi
© 2021 Meta ULC. All rights reserved