Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma

Oral Oncology
Maximilian MoergelMartin Kunkel

Abstract

The tumor suppressor homologue p63 is expressed in basal and parabasal layers of intraoral mucosa. Full length transcripts with transactivational domain (TA forms) present with homology to p53 and implicate functions governing cell proliferation, differentiation and apoptosis control. To date studies show an increase of p63 expression in oral dysplasia and additionally high expression levels correlated with poor prognosis for patients with OSCC, whereas a possible link to radiation resistance of tumors has not been investigated yet. In the present study we tested the hypothesis for p63 being a marker of radioresistance and overall survival in OSCC. p63 Expression was labeled by immunohistochemistry in pre-treatment biopsies collected from 33 patients with OSCC. Quantification of the labeling index (Li) based on the relation of p63 positive cells to overall tumor cell count. Histological examination of the resection specimen allowed categorization of the radiation response. Statistical analyses of the association between Li and radiation response were performed. Survival analysis utilized Kaplan-Meier estimates and additionally a Cox regression model was built for p63 (Li), T stage, N-stage and chemotherapy and presented as haza...Continue Reading

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Citations

May 4, 2012·Cancer Prevention Research·Mark C PierceAnn M Gillenwater
Aug 21, 2013·Clinical Oral Investigations·Maximilian MoergelMartin Kunkel
Apr 17, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Eik SchiegnitzBilal Al-Nawas
Jul 11, 2013·Histopathology·Tine M Søland, Ingvild J Brusevold
May 7, 2014·Oral Diseases·Mk SannigrahiM Khullar
Apr 24, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lotta LoljungKarin Nylander
Sep 25, 2012·Molecular Carcinogenesis·Lorenzo Lo MuzioMonica Emanuelli
Jan 21, 2016·Oral Diseases·Luís Silva MonteiroSaman Warnakulasuryia
Jan 18, 2013·Cell Cycle·Corrie L Gallant-Behm, Joaquín M Espinosa
Aug 28, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lihua HuAli Nawshad
Nov 17, 2017·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Sunit B PatelRakesh Sutariya
Nov 15, 2013·American Journal of Clinical Pathology·Galina Y StetsenkoPaul Nghiem
Jul 28, 2013·Virchows Archiv : an International Journal of Pathology·Marta NekulovaBorivoj Vojtesek
Dec 7, 2019·The Australasian Journal of Dermatology·Nataly PortillaRafael Parra-Medina
Feb 14, 2013·International Journal of Oncology·Masashi ShiibaHideki Tanzawa
Sep 25, 2014·Veterinary Pathology·L A MestrinhoM M R E Niza
Apr 2, 2020·Frontiers in Pharmacology·Debora GrassoPierre Sonveaux
Nov 30, 2019·Frontiers in Oncology·Mariano Francesco CaratozzoloApollonia Tullo
Apr 4, 2021·Cells·Flaviana MarzanoApollonia Tullo

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